The Expression of GP73 in Serum and Tissues of Patients with Chronic Hepatitis B，Liver Cirrhosis and Primary Live r Cancer

［Abstract］Objective　To study the expression of GP73 in the serum and tissue of patients with chronic hepatitis B， liver cirrhosis and primary liver cancer. Methods（1）Double-antibody sandwich ELISA was used to test the level of GP 73 in serum and tissue of of patients with chronic hepatitis B， liver cirrhosis and primary liver cancer and normal control group. 2. Immunohistochemical SP methods were used to test the level of GP 73 in serum and tissue of of patients with chronic hepatitis B， liver cirrhosis and primary liver cancer and normal control group. Results The expression of GP73 in the serum and tissue was irrelevant to sex and age. The expression levels of GP73 were increasing gradually in the patients with chronic hepatitis B and liver cirrhosis . GP73 was relevant to the progression of Chronic hepatitis B. The concentration of GP73 in the serum and tissue of the patients with chronic hepatitis B was relevant to AFP，HBV-DNA，and had a significant correlation with ALP．Conclusion　The expression of GP73 seems closely related to the occurrence and progression of hepatocarcinoma， which will be useful in the diagnosis and prognostic evaluation of hepatocarcinoma and in the conjecture of hepatic neoplasm and identification of Malignant Diseases，and will be a valuable marker of hepatocarcinoma.