Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma

Kang Qiang

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Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

Citation:

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

Citation:

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

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Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma

Kang Qiang

(Dept. of Hepatpbiliary Surgery,The 2nd Affliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

Abstract

Abstract

［Abstract］Objective　To discuss the relationship between the expression of E-cadherin and Vimentin and pathological characteristics in intrahepatic cholangiocarcinoma（ICC）. Methods The expression of E-cadherin and Vimentin was detected by immunohistochemistry in ICC and para-carcinoma intrahepatic bile duct（n＝50）.The correlation between the expression of tumor tissues and the clinicopathological characteristics of ICC was analyzed， and their prognostic implication was evaluated. Results　The expression of E-cadherin was significantly lower in ICC than in matched as the upper mentioned tissues （42%vs68%，P＜0.05）.The expression of Vimentin was significantly higher in intrahepatic cholangiocarcinoma （ICC） than matched as the upper mentioned tissues（50%vs30%，P＜0.05）. Down-regulation of E-cadherin and up-regulation of Vimentin were significantly associated with TNM stage，differentiation，lymph node metastasis of ICC （P< 0.05）.For the survival analyses，low E-cadherin expression and positive Vimentin expression were significantly associated with shorter survival（P＜0.05）．Conclusion Low expression of E-cadherin and high expression of Vimentin in the intrahepatic cholangiocarcinoma（ICC）are correlated with the invasion， migration and poor prognosis， and have clinical significance in judging the prognosis of patients.
- ［Key words］Intrahepatic cholangiocarcinoma；E-cadherin；Vimentin；EMT,

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