Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma

Kang Qiang

Article Contents

Article Navigation > Journal of Kunming Medical University > 2016 > 37(04):

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

Citation:

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

Citation:

Kang Qiang . Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma[J]. Journal of Kunming Medical University, 2016, 37(04).

PDF( 542 KB)

Expression of E-cadherin and Vimentin and Clinic Significance in Intrahepatic Cholangiocarcinoma

Kang Qiang

(Dept. of Hepatpbiliary Surgery,The 2nd Affliated Hospital of Kunming Medical University,Kunming Yunnan 650101,China)

Abstract

Abstract

［Abstract］Objective　To discuss the relationship between the expression of E-cadherin and Vimentin and pathological characteristics in intrahepatic cholangiocarcinoma（ICC）. Methods The expression of E-cadherin and Vimentin was detected by immunohistochemistry in ICC and para-carcinoma intrahepatic bile duct（n＝50）.The correlation between the expression of tumor tissues and the clinicopathological characteristics of ICC was analyzed， and their prognostic implication was evaluated. Results　The expression of E-cadherin was significantly lower in ICC than in matched as the upper mentioned tissues （42%vs68%，P＜0.05）.The expression of Vimentin was significantly higher in intrahepatic cholangiocarcinoma （ICC） than matched as the upper mentioned tissues（50%vs30%，P＜0.05）. Down-regulation of E-cadherin and up-regulation of Vimentin were significantly associated with TNM stage，differentiation，lymph node metastasis of ICC （P< 0.05）.For the survival analyses，low E-cadherin expression and positive Vimentin expression were significantly associated with shorter survival（P＜0.05）．Conclusion Low expression of E-cadherin and high expression of Vimentin in the intrahepatic cholangiocarcinoma（ICC）are correlated with the invasion， migration and poor prognosis， and have clinical significance in judging the prognosis of patients.
- ［Key words］Intrahepatic cholangiocarcinoma；E-cadherin；Vimentin；EMT,

FullText(HTML)

References(0)

References

Relative Articles(20)

Relative Articles

[1]	Xiaobing GUO, Xiaowen LI, Hengxi LI, Yan CAO, Ping LI. miR-212-3p Targeted Regulation of NAP1L1 Inhibits Glioma Cell Proliferation，Migration and EMT. Journal of Kunming Medical University, 2024, 45(11): 22-30. doi: 10.12259/j.issn.2095-610X.S20241104
[2]	Peng LI, Renchao ZOU, Longao DAI, Songzhou FU, Dong WEI, Bo TANG. The Effect of HIF-1α on Invasion and Metastasis of Gallbladder Cancer by Regulating the Epithelial-Mesenchymal Transformation. Journal of Kunming Medical University, 2024, 45(5): 44-48. doi: 10.12259/j.issn.2095-610X.S20240507
[3]	Rongyu YANG, Fei SONG, Hao HUANG, Kaiwen DUAN, Yingying XIANG. Application of Bone Marrow Mesenchymal Stem Cells in Stomatology. Journal of Kunming Medical University, 2023, 44(3): 155-159. doi: 10.12259/j.issn.2095-610X.S20230323
[4]	Xilan WU, Hong SHEN, Susheng SHI, Zhihui ZHANG, Lei GUO, Fang WANG. The Expression of PD-L1, BRAF^V600E, CD68 Protein and the Significance of Tumor Infiltrating Lymphocytes in the Diagnosis of Malignant Melanoma. Journal of Kunming Medical University, 2022, 43(9): 13-18. doi: 10.12259/j.issn.2095-610X.S20220923
[5]	Hongjiang ZHOU, Juan TANG, Lei LIANG, Xin NIAN. Research Progress of Akkermansia Muciniphila and Obesity-related Metabolic Diseases. Journal of Kunming Medical University, 2022, 43(1): 157-162. doi: 10.12259/j.issn.2095-610X.S20220143
[6]	Fei BI, Weihua GUO. Advances in Research on Hertwig’s Epithelial Root Sheath Cells. Journal of Kunming Medical University, 2022, 43(6): 159-166. doi: 10.12259/j.issn.2095-610X.S20220628
[7]	Jing-hui LI, Ming ZHU, Hai QU, Qiu-yu LI, Yu-juan WU, He-ying YANG, Yu-zhu WANG, Yan-ping LI. miR-490-3p Suppresses EMT of SW1990 Pancreatic Cancer Cells. Journal of Kunming Medical University, 2021, 42(3): 10-17. doi: 10.12259/j.issn.2095-610X.S20210305
[8]	Wang Fu Ke , Zhang Hong , Yang Gui Ran , Xiao Yu , He Chuan , Song En , Li Yan Lin . . Journal of Kunming Medical University, 2019, 40(05): 24-30.
[9]	Lu Die Qing . Association Analysis between Genetic Polymorphisms of CYP4A11, Apolipoprotein B and E Genes and Essential Hypertension Susceptibility. Journal of Kunming Medical University, 2018, 39(05): 70-77.
[10]	Yang Dan . Effect of Paracrine Function of Mesenchymal Stem Cells on Diabetic Nephropathy. Journal of Kunming Medical University,
[11]	Tang Bang Li . Therapeutic Effects and Mechanism of Umbilical Cord Derived Mesenchymal Stem Cell Transplantation for Lupus Nephritis. Journal of Kunming Medical University,
[12]	Yi Min . . Journal of Kunming Medical University,
[13]	Tang Ying . . Journal of Kunming Medical University, 2015, 36(08): 1-1.
[14]	Tai Wen Lin . . Journal of Kunming Medical University,
[15]	Zhou JieYan . . Journal of Kunming Medical University,
[16]	Qi Zong Ze . . Journal of Kunming Medical University,
[17]	Wang Dian Hua . . Journal of Kunming Medical University,
[18]	Tai Wen Lin . Anti-inflammatory,Analgesic and Choleretic Effect of Lidan Zhitong Capsulen Mice. Journal of Kunming Medical University,
[19]	. Inducing Differentiation of Pig's Bone Mesenchymal Stem Cell(BMSC) to Urothelial Epithelia in Vitro. Journal of Kunming Medical University,
[20]	. The Expressions and Significance of ADAM10,EGFR and E-cadherin in Hepatocellular Carcinoma. Journal of Kunming Medical University,