Long-term Effects of Palliative Surgery and Pancreaticoduodenectomy in Treatment of Pancreatic Cancer and Ampulla Surrounding Cancer

［Abstract］Objective　To research the long-term effects of palliative surgery and pancreaticoduodenectomy in treatment of pancreatic cancer and ampulla surrounding cancer. Methods Forty-four patients with pancreatic cancer joint periampullary cancer，who were admitted in our hospital for treatment from April 2002 to April 2014， were randomly divided into observation group and control group ， with 22 cases in each group. Patients in the control group were treated with palliative surgery，patients in the observation group were treated with pancreaticoduodenectomy treatment. The blood loss，operative time，hospital stay，complications， survival of change，radical resection rate and relapse rate changes of two groups were compared．Results　Compared with control group，in the observation group，the blood loss increased， and the time of the surgery extended. And the difference was statistically significant（P <0.05）. The hospital stay of patients in the two groups were compared， and there was no significant difference（P＞0.05）. The overall incidence of complications of the observation group （54.55%）was significantly higher than that of the control group（22.73%），and the difference was statistically significant（P＜0.05）. The complication rate of the observation group was significantly higher than that of the control group，and the difference was statistically significant（P＜0.05）. Survival status of the two groups were compared， in the observation group， the number of survival cases during 2 years increased more significantly than that of the control group， and the difference was statistically significant（P＜0.05）. The radical resection rate after surgery and recurrence rate of the two group were compared， and the difference was not statistically significant （P> 0.05）. Conclusions　Compared with palliative surgery in treatment of pancreatic cancer joint periampullary cancer， pancreatoduodenectomy treatment may increase the blood loss，extend the operative time and increase the complication rate， but significantly improve the long-term survival rate.