The Proteomics Research of Sjogren's Syndrome

［Abstract］Objective　To investigate the specific differentially expressed proteins in sjogren's syndrome by SELDI . Methods　We selected the CM10 Chip and SELDI technology to compare the difference in the proteins expression between SS and health， joint swelling pain group and without joint swelling pain group. Results（1）There were 68 different mass spectrum peak between SS group and normal group（P < 0.05）， and identified 11 differently expressed proteins，including 10 of upreguated and 1 downregulated protein. （2）No specific proteins were found in the joints swelling pain group. （3）The 11 different proteins were analyzed respectively with clinical data， but no correlation was found. Conclusions（1）There are difference in serum proteins express between SS patients and normal subjects.（2）The joint swelling pain symptoms in SS patients is non-specific. （3）The alpha 1 chymotrypsin，fibrinogen aa chain，beta amyloid precursor protein and thyroid hormone，β2 -microglobulin are associated with SS and can result in amyloidosis， the mechanism may be associated with amyloidosis.