The Correlation between Vitamin D Receptor Gene FokI Single Nucleotide Polymorphism and Diabetic Kidney Disease

［Abstract］Objetive To investgate the correlation of Vitamin D receptor gene FokI single nucleotide polymorphism with diabetic kidney disease in type 2 diabetic patients．Methods　The single nucleotide polymorphism of VDR gene in 235 type 2 diabetes， [including 82 normal albuminuria（DKD0 group），66 microalbuminuria（DKDl group ）and 87 macroalbuminuria（DKD2 group）]and 86 normal controls were detected by TaqMan real-time polymerase chain reaction. The genotype frequency and allele frequency and relative clinical data were compared among groups. Results（1）FokI CC，TC，TT genotype frequencies were 25.23%， 53.27%，21.50%，allele C and allele T frequencies were 51.87% and 48.13% in overall populations. （2）The genotype frequency and allele frequency among groups had no statistically significant difference（P＜0.05）. （3） Logistic multiple regression analysis showed that FokI C allele was not related to T2DKD occurrence（OR=2.040，P＝0.05），but was related to T2DKD development（OR＝4.741，P＝0.004）. Conclusion　VDR gene FokI C allele is associated with the risk of T2DKD development.