Zhong Lian Mei . The Activation and Polarization of Microglia in Epileptic Rats Induced by Pilocarpine[J]. Journal of Kunming Medical University, 2016, 37(05).
Citation: Zhong Lian Mei . The Activation and Polarization of Microglia in Epileptic Rats Induced by Pilocarpine[J]. Journal of Kunming Medical University, 2016, 37(05).

The Activation and Polarization of Microglia in Epileptic Rats Induced by Pilocarpine

  • [Abstract]Objective To explore the activition and polarization of microglia in the epileptic rats induced by lithium chloride-pilocarpine. Methods One hundred male SD rats were randomly divided into five groups: control group and different time points model groups including 1d,3d,7d and 14d. Epilepsy models were established by lithium chloride-pilocarpine intraperitoneal injection. The control group was given the same dosage of normal saline. The morphology change was detected by immunofluorescence, and the expressions of iNOS and Arg-1 were determined by IHC at respective time points. Results Compared the model groups with control group, microglia was activated, synapsis was shorten,volume got bigger, most of them seemed as amoebocyte, the expression of iNOS increased and Arg-1 decreased,especially at 3d.Conclusion The results from this study indicated that microglia was activated and polarized in epileptic rats induced by pilocarpine.
  • loading
  • Relative Articles

    [1] Lin ZHU, Yi LI, Kerong CHEN, Yonghua ZHANG, Hongling SHI. The Application and Research of Functional Near-infrared Spectroscopy in Epilepsy. Journal of Kunming Medical University, 2024, 45(5): 178-183.  doi: 10.12259/j.issn.2095-610X.S20240527
    [2] Yike TANG, Rencai LU, Yunhai JI, Bo SHE, Yanping QING. Effect of Reasonable Sedation on Image Quality before PET/CT Examination in Children with Epilepsy. Journal of Kunming Medical University, 2022, 43(11): 178-184.  doi: 10.12259/j.issn.2095-610X.S20221124
    [3] Ming YAN, Jian-yun YU, Sheng-jie NIE, Yong-qiang QU, Shang-wen WANG, Rui WANG, Jun-jie SHU, Huan LIU, Shu-hua LI. Metabonomics of Scopolamine Intoxication in Rats. Journal of Kunming Medical University, 2021, 42(4): 13-19.  doi: 10.12259/j.issn.2095-610X.S20210403
    [4] Xia-rong GONG, Li-gong BIAN, Yu-hui CHEN, Jing CHEN, Bo WANG, Guo-li BI. A Study on Diffusion Kurtosis Imaging in Acute Epilepsy Rats. Journal of Kunming Medical University, 2021, 42(4): 28-32.  doi: 10.12259/j.issn.2095-610X.S20210405
    [5] Han Juan , Xu Hong . . Journal of Kunming Medical University, 2018, 39(10): 68-71.
    [6] Zhang Wei . Effect of SGK1 on the Protection of Ischemia Reperfusion Model Rats. Journal of Kunming Medical University,
    [7] Tian Wei . Liraglutide Improves The Symptoms of Non-alcoholic Fatty Liver Disease by Regulating Fatty Acid β-oxidation. Journal of Kunming Medical University,
    [8] Huang Wei Min . . Journal of Kunming Medical University,
    [9] Li Hong Li . . Journal of Kunming Medical University,
    [10] Xiong Yu Xin . . Journal of Kunming Medical University,
    [11] Wang Jian . . Journal of Kunming Medical University,
    [12] Tian Jin Tao . . Journal of Kunming Medical University,
    [13] Yang Li . . Journal of Kunming Medical University,
    [14] Zhao Chun Mei . . Journal of Kunming Medical University,
    [15] Li Yu Lian . . Journal of Kunming Medical University,
    [16] . Effects of Exercise Training on Glucose Intolerance in Rats with Type 2 Diabetes Induced by Alloxan. Journal of Kunming Medical University,
    [17] Liu Xiao Ming . The Study of the Immune Tolerance Induced by PD-L1Ig in Rat Liver Transplantation. Journal of Kunming Medical University,
    [18] . Effects of Cyclosporine A on RAF-1 Expression in Skeletal Muscles of Hindlimbs in Adult Rats after Spinal Cord Transaction. Journal of Kunming Medical University,
    [19] Wang Zhao Jun . . Journal of Kunming Medical University,
    [20] Zhang Yun Qiang . . Journal of Kunming Medical University,
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (3718) PDF downloads(361) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return