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Citation: Li Li . Effect of Geraniin on Expression of Wnt3a in BMSC from Osteoporotic Rats[J]. Journal of Kunming Medical University, 2016, 37(06).
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Effect of Geraniin on Expression of Wnt3a in BMSC from Osteoporotic Rats

  • (1)Dept. of Pharmacy,The 3rd Afiliated Hospital of Kunming Medical University,Kunming Yunnan 650118;2)Pharmaceutical College & Key Laboratory of Pharmacology for Natural Products of Yunnan Province,Kunming Medical University,Kunming Yunnan 650500,China)

    Abstract
  • ［Abstract］Objective To investigate the effect of geraniin on expression of Wnt3a protein and mRNA in bone marrow stromal cell （BMSC） from osteoporotic rats. Methods The model of osteoporosis （OP） was duplicated by ovariectomy in rats. BMSCs were isolated and cultured. BMSCs from shamed rats were routinly cultured and taken as normal control， and BMSCs from OP rats were divided into model group， 1 μmol/L simvastatin positive group， and geraniin group （0.01， 0.1， 1， 10， 100 μmol/L）， respectively. The methods of realtime-PCR and western blot were used to assay the protein and mRNA expression of wnt3a， respectively．Results　As compared with normal control group， the protein and mRNA expression of wnt3a in model group were significantly suppressed; Compared with model group， 1 μmol/L simvastatin， and 0.1， 1， 10 and 100 μmol/L geraniin significantly increased the expression of wnt3a protein and mRNA. Conclusion　It is suggested that geraniin activates wnt/β-catenin pathway though increasing the expression of signaling protein wnt 3a in BMSCs from OP rats. It would be beneficial to osteogenic differentiation of BMSCs and osteogenesis.
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