Meta Analysis of ADAM33 T1，S2 Polymorphism and the Susceptibility of Bronchial Asthma in China

［Abstract］Objective To investigate the correlation between ADAM33 T1， S2 gene polymorphism and Bronchial asthma risk in china. Methods We retrived the relevant published studies about ADAM33 T1，S2 gene polymorphism and bronchial asthma risk. Then we divided the population into Chinese and other Asian population. Odds ratio（OR）of Case group and control group was selected as the effect index. Stata 11.0 software was used to calculate heterogeneity test，ORs and 95%CI of two areas，and gave the forest plot and funnel plot of meta results. Results A total of 27 studies were included in this analysis，18 studies in ADAM33 T1 site were 3881 cases in case group， and 3780 cases in control group; and 14 studies in ADAM33 S2 site were 3222 cases in case group，and 3513 cases in control group. Additive model，dominant model，recessive model of ADAM33 T1 in Chinese had association with the susceptibility of bronchial asthma. The results were OR=1.488，95% CI：1.002-2.167 in Additive model， OR=1.619，95%CI：1.059-2.475 in dominant model；OR=2.523，95%CI：1.910-3.333 in recessive model. Three models of ADAM33 T1 in other Asian country had no association with the susceptibility of Bronchial Asthma. Three gene model of ADAM33 S2 in Asian had no association with bronchial asthma susceptibility. Except ADAM33 T1 polymorphism in recessive model， other mode of T1， S2 had no publication bias in Chinese population. Conclusion There are association between ADAM33 T1 gene polymorphism and bronchial asthma， but ADAM33 S2 gene polymorphism and bronchial asthma have no association in Chinese population.