The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer

Hong Chao

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Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

Citation:

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

Citation:

Hong Chao . The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer[J]. Journal of Kunming Medical University, 2016, 37(06).

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The Correlation of CDH13 Gren Variation with Non-small Cell Lung Cancer

Hong Chao

(1)Institute of Medical Biology,Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118;2)Dept. of Geriatrics,The No.1 Affiliated Hospital of Kunming Medical University, Kunming 650032;3)Dept. of Thoracic Surgery,The No.3 Affiliated Hospital of Kunming Medical University,Kunming 650118,China)

Abstract

Abstract

［Abstract］Objective To evaluate the correlation of the single nucleotide polymorphisms （SNPs） in CDH13 with non-small cell lung cancer （NSCLC）. Methods 115 patients with NSCLC and 110 healthy controls were included in present study. Two SNPs （rs11646213 and rs7195409） in CDH13 were genotyped using TaqMan method. The association of these two SNPs with NSCLC was calculated and assessed. Results The genotypic and allelic frequencies of rs11646213 showed significant difference between NSCLC patients and the control group （P＜0.05），（OR＝0.464，95% CI：0.273～0.789）. The genotypic and allelic frequencies of rs7195409 showed significant difference between the stage I+II and stage III+IV groups （P＜0.05），（OR＝0.491，95% CI：0.243～0.991）. Conclusions　The rs16146213 has a strong association with NSCLC and G allelic showed a protective effect. The rs7195409 has a strong association between stage I+II and III + IV in NSCLC， and G allele may play a protective role in the development of NSCLC.
- ［Key words］Non-small cell lung cancer ；CDH13；Single-nucleotide polymorphisms,

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