The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood

Li Peng

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Li Peng . The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood[J]. Journal of Kunming Medical University, 2016, 37(06).

Citation:

Li Peng . The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood[J]. Journal of Kunming Medical University, 2016, 37(06).

Li Peng . The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood[J]. Journal of Kunming Medical University, 2016, 37(06).

Citation:

Li Peng . The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood[J]. Journal of Kunming Medical University, 2016, 37(06).

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The Difference in the Concentration of Insulin and c-peptide in Portal Vein and Peripheral Blood

Li Peng

(1)Medical Faculty,Kunming University of Science and Technology,Kunming 650500; 2)Dept. of Hepatobiliary Surgery,The First People’s Hospital of Yunnan Province;3)Dept. of Endocrinology,Kunming 650032,China)

Abstract

Abstract

［Abstract］Objective　To analyze the concentration changes of insulin and c peptide of in portal vein and peripheral blood， and explore the feasibility of using insulin and c peptide concentration changes in assessment of liver function. Methods The portal vein and peripheral blood samples were extracted from 82 clinical liver cancer patients，and the insulin and c peptide concentration were detected. The differences in the insulin and c peptide concentration in portal vein and peripheral blood were statistically analyzed. Results The insulin concentration in the portal vein and peripheral blood values were 32.43 μ U/ml and 8.05 μ U/ml， respectively， there was a significant difference（P＜0.05）. The c-peptide concentration in the portal vein and peripheral blood values were 1.38 μU/mL and 1.19 μg U/mL， respectively， there was no significant differences（P＞0.05）. Conclusion Liver metabolizes insulin as the target organ of insulin， while c-peptide dose not be metabolized in vivo， so it is possible to assess liver function by comparative analysis of the metabolic rate of insulin and c-peptide changes.
- ［Key words］Portal vein blood； Peripheral blood；Insulin；C-peptide；Liver function,

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