The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients

Huang Hong

Volume 37 Issue 07

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Huang Hong . The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients[J]. Journal of Kunming Medical University, 2016, 37(07).

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Huang Hong . The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients[J]. Journal of Kunming Medical University, 2016, 37(07).

Huang Hong . The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients[J]. Journal of Kunming Medical University, 2016, 37(07).

Citation:

Huang Hong . The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients[J]. Journal of Kunming Medical University, 2016, 37(07).

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The Correlation of ACE I/D Gene Polymorphisms with the Antihypertensive Efficacy of Irbesartan Among Hypertensive Patients

Huang Hong

(1)Dept. of Gerontology,First People’s Hospital of Yunnan Province,Kunming Yunnan 650032;2)Experiment Center for Medical Science Research,Kunming Medical University,Kunming Yunnan 650500;3)The Second People’s Hospital of Dehong,Dehong Yunnan 678400,China)

Abstract

Abstract

［Abstract］Objective To analyze the correlationship of ACE I/D gene polymerphisms with the anti-hypertensive efficacy of irbesartan among essential hypertension（EH） patients in Yunnan han people. Methods One hundred EH patients hypertension were treated with irbesartan 150mg once daily for 4 weeks， and anti-hypertensive efficacy were monitored during the treatment. Results　There was a significant difference between anti-hypertensive efficacy of irbesartan among different genotype groups， DD group＞ID group＞II group（P ＜0.05）．Conclusions　There is different therapy responsiveness in diffenent genotypes. ACE I/D polymorphism may be an important hereditary factor that impacts the efficacy of irbesartan.
- ［Key words］Yunnan；Han ethnic；Essential hypertension；ACE gene；Gene polymorphism；Irbesartan；Efficacy,

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