Research Progress of Galectin in Mchanism of Venous Trombosis

［Abstract］Galectins are a family of carbohydrate-binding proteins that have a high affinity to galactosides on cell surfaces and extra cellular glycoproteins. They are involved in a variety of biological functions， including modulation of cell apoptosis， cell activation and inflammation. Our laboratory has recently identified galectin-3 binding protein（Gal-3BP）as being up-regulated in a microparticle proteomics analysis for deep venous thrombosis（DVT） patients compared to negative controls. P-selectin，another glycoprotein involved in thrombus propagation， has been proved as a promising target for DVT management and has been widely studied by our group. Galectins are involved in P-selectin expression and can potentially be implicated in the venous thrombogenesis process.Interleukin-6，as an important cytokine of body，which have been found in the study of inflammation for venous thromboembolism，may be an important factor for the frmation of VT. Research shows gal3bp:gal3 plays a critical role in VT， likely via IL-6 Promote thrombosis.The function of galectins， their role in inflammation and thrombosis as well as their potential implications as a new pharmacological target for DVT management are reviewed in this manuscript.