Distribution and Drug Resistance of Carbapenem-resistant Citrobacter Freundii from 2012 to 2014

［Abstract］Objective　To investigate the distribution and susceptibility of carbapenem resistant citrobacter freundii for rational antimicrobial therapy. Methods The C.freumdii were collected between January 2011 and December 2014 from inpatients. The minimum inhibitory concentration（MIC） were detected by an automated analyzer（VITEK 2）to analyze the characteristic of tested bacteria. Results（1）Of the 21 strains of carbapenem-resistant citrobacter freundii，95% were collected from urine， among which most of the strains were isolated from the Department of Transplantology（66.7%）and Urology（19%）；（2）Antimicrobials Susceptibility test showed that Citmbacter freund were highly resistant to Cephalosporins and relevant beta -lactamase inhibitors．Even carbapenem were highly resistant.Imipenem had a resistance rate of 90%（95% confidence interval :70 to 99），Meropenem 85.7%（95% confidence interval:64 to 97），The drug resistance rate to Amikacin was only 4.8%，followed by Nitrofuran toin（10.5%）and Fosfomycin（15%）. Conclusions　Carbapenem resistant citrobacter freundii，which often causes urinary tract infection in our hospital，was characterized by multi-drug resistant （MDR）. Monitoring of the Citrobaeter freundii should be strengthened to control the prevalence of drug resistance.