Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen

He Yun Fa

Article Contents

Article Navigation > Journal of Kunming Medical University > 2016 > 37(09):

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

Citation:

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

Citation:

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

PDF( 178 KB)

Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen

He Yun Fa

(1)School of Public Health,Kunming Medical University,Kunming Yunnan 650500;2)Yunnan Center for Disease Prevention and Control,Kunming Yunnan 650000,China)

Abstract

Abstract

［Abstract］Objective　To provide safety reference for the development of anti-cancer drugs by evaluating thetoxicological safety of the anticancer bioactive fraction AMH-T of lichen through the understanding of its poisonous nature and the intensity. Methods　Acute toxicity test， bone marrow micronucleus test in mice，sperm malformation test in rats， Ames test and short-term repeat drug test in mice were conducted. Results　Male mice were injected LD50 of 147 mg/kg and female mice 171 mg/kg. Conclusion　Injection of AMH-T has acute toxicity and liver toxicity，but has no genetic toxicity.
- ［Key words］Lichen；Anti-cancer drug；Acute toxicity；Genotoxicity；Toxicology,

FullText(HTML)

References(0)

References

Relative Articles(20)

Relative Articles

[1]	Lingjun SHEN, Longfen LI, Chunjing SHI, Wenming LI, Yuanqing HUANG, Huajie ZHANG, Yun LUO, jie LI, Li LIU. Factors Influencing the Development of Extra-Pulmonary Tuberculosis in Patients with Viral Hepatitis Complicated by Pulmonary Tuberculosis. Journal of Kunming Medical University, 2024, 46(): 1-7.
[2]	Baining QIU, Yuebing WANG, Wu LONG, Sijie WEI, Rui WANG, Lin MA, Yanmei XI, Xue TANG, Puping LEI. Toxicity Differences of Amanita Manginiana in Seven Villiages in Yunnan Province. Journal of Kunming Medical University, 2024, 45(8): 145-153. doi: 10.12259/j.issn.2095-610X.S20240821
[3]	Xuemei CHEN, Pin GUO, Liufang CHUAN, Zi WANG, Xuejiao LI, Wenji HE. Evaluation of Cardiac Toxicity of Anthracyclines in Children with Acute Leukemia Based on Tei Index. Journal of Kunming Medical University, 2024, 45(2): 117-122. doi: 10.12259/j.issn.2095-610X.S20240216
[4]	Zhiye QI, Ying CHEN, Yan LI. Research Progress on Immunotoxicology of Pyrethroid Pesticides Exposures. Journal of Kunming Medical University, 2024, 45(8): 154-160. doi: 10.12259/j.issn.2095-610X.S20240822
[5]	Yue XU, Chan WANG, Shucheng LIN, Huijie ZHANG, Yi TAN, Shuwei ZHANG, Xiaofeng ZENG, Zhen LI. Advances in the Mechanism of Hepatotoxic Effects Induced by α-amanitin. Journal of Kunming Medical University, 2022, 43(12): 153-158. doi: 10.12259/j.issn.2095-610X.S20221228
[6]	Yuan-yuan LI, Juan LI, Gen-meng YANG, Jian HUANG, Liu LIU, Bao-yu SHEN, Chan WANG, Yue XU, Shu-cheng LIN, Xiao-feng ZENG. Research Progress on Neurotoxic Effects and Mechanism of Methamphetamine. Journal of Kunming Medical University, 2021, 42(2): 153-157. doi: 10.12259/j.issn.2095-610X.S20210210
[7]	Zhang-ping ZHOU, Xiao-qiong HE, Ling DUAN, Song TENG, Zhuo-xuan LIANG. Evaluation of Toxicology and Safety of Natural Active Compound Usenamine. Journal of Kunming Medical University, 2021, 42(6): 22-28. doi: 10.12259/j.issn.2095-610X.S20210642
[8]	Zhu Xing Lei , Zhang Ling . . Journal of Kunming Medical University, 2020, 41(05): 13-17.
[9]	Lv Song Qin , Huang Shan , Li Xiao Fei , Shi Jin Li , Li Guang Min , Duan Hong Fen . Application of T-lymphocyte Subsets for Non-viral Liver Disease. Journal of Kunming Medical University, 2019, 40(03): 107-111.
[10]	Hai Qing Shan , Ma Xiao Xia , Yang Yu Qing , Yang Zhu Ya . Comparation of Three Kinds of Diterpenoid Alkaloid from Aconitum bulleyanum Diels in Related Pharmacodynamics and Toxicity. Journal of Kunming Medical University, 2017, 38(01): 18-22.
[11]	Zhang Lan Chun , Wang Shang Wen , Hu Wei Yan , Zhao Rong Hua , Yu Hao Fei , Zhang Rong Ping . Protective Effects of Rosemary's Extract on Cerebral Ischemia in Mice and Acute Toxicity Evaluation. Journal of Kunming Medical University, 2016, 37(12): 16-19.
[12]	He Yun Fa , He Xiao Qiong , Jiang Zhong Yang , Wang Jing , Hu Song Shan , Shui Jing Lin . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen. Journal of Kunming Medical University, 2016, 37(11): 1-4.
[13]	Zhao Jing Yun . . Journal of Kunming Medical University,
[14]	Bian Hai Xia . . Journal of Kunming Medical University,
[15]	Ma Yan Li . . Journal of Kunming Medical University,
[16]	Li Bin . . Journal of Kunming Medical University,
[17]	Wei Dan Xia . . Journal of Kunming Medical University,
[18]	Liu Ju Peng . . Journal of Kunming Medical University,
[19]	Liu Ru Wen . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,