Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen

He Yun Fa

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He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

Citation:

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

Citation:

He Yun Fa . Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen[J]. Journal of Kunming Medical University, 2016, 37(09).

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Toxicological Study on the Anticancer Bioactive Fraction AMH-T of Lichen

He Yun Fa

(1)School of Public Health,Kunming Medical University,Kunming Yunnan 650500;2)Yunnan Center for Disease Prevention and Control,Kunming Yunnan 650000,China)

Abstract

Abstract

［Abstract］Objective　To provide safety reference for the development of anti-cancer drugs by evaluating thetoxicological safety of the anticancer bioactive fraction AMH-T of lichen through the understanding of its poisonous nature and the intensity. Methods　Acute toxicity test， bone marrow micronucleus test in mice，sperm malformation test in rats， Ames test and short-term repeat drug test in mice were conducted. Results　Male mice were injected LD50 of 147 mg/kg and female mice 171 mg/kg. Conclusion　Injection of AMH-T has acute toxicity and liver toxicity，but has no genetic toxicity.
- ［Key words］Lichen；Anti-cancer drug；Acute toxicity；Genotoxicity；Toxicology,

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