Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing

Li Fei

Volume 37 Issue 10

Sep. 2020

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Li Fei . Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing[J]. Journal of Kunming Medical University, 2016, 37(10).

Citation:

Li Fei . Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing[J]. Journal of Kunming Medical University, 2016, 37(10).

Li Fei . Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing[J]. Journal of Kunming Medical University, 2016, 37(10).

Citation:

Li Fei . Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing[J]. Journal of Kunming Medical University, 2016, 37(10).

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Effect of Celebrex on the Hemorheology and Levels of Inflammatory Factors in Patients with Delayed Fracture Healing

Li Fei

(1)Dept. of Orthopaedics,Fugu County People’s Hospital,Fugu Shaanxi 719400;2)Dept. of Radiology,Yunnan Provincial Hospital of Traditional Chinese Medicine,Kunming Yunnan 650022,China)

Publish Date: 2020-09-27

Abstract

Abstract

［Abstract］Objective　To investigate the effect of Celebrex on hemorheology and levels of serum intercelluar adhesion molecule-1（sICAM-1），serum vascular cell adhesion molecule-1（sVCAM-1），tumour necrosis factor-α（TNF-α），interleukin-6 （IL-6） in patients with delayed fracture healing. Methods 201 patients with delayed fracture healing in our hospital were randomly divided into observation group（n＝101）and control group （n＝100）. The patients in control group received conventional surgical internal fixation，while patients in observation group received conventional surgical internal fixation combined with Celebrex. The clinical efficacy was observed， while the changes of hemorheology and levels of sICAM-1， sVCAM-1， TNF-α， IL-6 were compared between two groups before and after treatment．Results　The effective rate of observation group was 94.1%， which was significant higher than that of control group 70.0%（P＜0.01）. There were no significantly differences between two groups in the indexes of hemorheology and levels of sICAM-1，sVCAM-1，TNF-α，IL-6 before treatment（P＞0.05）. The indexes of hemorheology and levels of sICAM-1，sVCAM-1，TNF-α，IL-6 were significantly reduced after treatment， while the decreased degrees of observation group were better than those of control group，with statistically significant difference（P＜0.05）. Conclusions　Celebrex can improve the indexes of hemorheology，reduce the levels of sICAM-1，sVCAM-1， TNF-α， IL-6 and improve the clinical effect in treatment of delayed fracture healing. It is worth of popularization and application.
- ［Key words］Celebrex；Delayed fracture healing；Hemorheology；Inflammatory factors,

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