Correlation of Apelin，Vaspin，Leptin with Endometrial Cancer

［Abstract］Objective　To detect the expression of Apelin，Vaspin and Leptin in serum， and to understand the relationship between the expression of Vaspin and Apelin，and the relationship between Leptin and I type of endometrial carcinoma. Methods　We recorded the age，height，weight of patients， measured the blood pressure，and recorded the complete case data， and calculated the body mass index， then determined the serum Apelin and vaspin，leptin protein expression by enzyme linked immunosorbent assay（ELISA）. Results　When 18.5≤BMI＜25 or BMI≥25， compared with the control group， the serum Apelin，vaspin，leptin of patients in the endometrial carcinoma group had statistically significant difference. In endometrial carcinoma group，the serum levels of three kinds of adipokines（Apelin and vaspin and leptin）had statistically significant difference between patients with 18.5≤BMI＜25 and BMI≥25. EC occurrence was correlated with BMI，diabetes，and high cholesterol hyperlipidemia，E2，HOMA-IR，serum Apelin，vaspin， leptin．Conclusions　The patients with type I endometrial cancer express three kinds of fat factor，and the expression levels are significantly higher than the normal group. The occurrence of EC is related with BMI，diabetes，hyperlipidemia，E2，HOMA-IR，serum Apelin，Vaspin，Leptin.