Comparative Study on Releasing Characteristics of Paclitaxel Chitosan Membranes by Two Different Preparative Methods

Song Fei; Xiang Ying Ying; Mao Zhi Jian; Zhang Xiao Wen

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Song Fei , Xiang Ying Ying , Mao Zhi Jian , Zhang Xiao Wen . Comparative Study on Releasing Characteristics of Paclitaxel Chitosan Membranes by Two Different Preparative Methods[J]. Journal of Kunming Medical University, 2017, 38(01): 1-7.

Citation:

Song Fei , Xiang Ying Ying , Mao Zhi Jian , Zhang Xiao Wen . Comparative Study on Releasing Characteristics of Paclitaxel Chitosan Membranes by Two Different Preparative Methods[J]. Journal of Kunming Medical University, 2017, 38(01): 1-7.

Citation:

Song Fei , Xiang Ying Ying , Mao Zhi Jian , Zhang Xiao Wen . Comparative Study on Releasing Characteristics of Paclitaxel Chitosan Membranes by Two Different Preparative Methods[J]. Journal of Kunming Medical University, 2017, 38(01): 1-7.

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Comparative Study on Releasing Characteristics of Paclitaxel Chitosan Membranes by Two Different Preparative Methods

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基金：国家自然科学基金资助项目 (81260084);

Received Date: 2016-10-12

Abstract

Abstract

Objective To compare the sustained release characteristics of paclitaxel chitosan membranes prepared by two different methods.Methods We prepared PTX-Suc-HECTS sustained release film and P-PTX-SRM release film by different methods.Then we measured the PTX loaded in chitosan membrane with FTIR, measured the best of factors for equilibrium swelling degree in the two sustained release membranes with multifactors orthogonal experiment, measured the standard curve of PTX, measured the two sustained release membrane in vitro PTX release curve.According to the standard curve, we also measured and compared the drug rate between two kinds of sustained-release film release in vitro.Results PTX was loaded in the chitosan sustained release film.The best of equilibrium swelling factors for PTX-Suc-HECTS sustained-release membrane were 250 mg Suc-HECTS, 1 mg/m L EDC-HCl and DMAP aqueous solution, 1h the cross-linking time, 1∶100cross-linking ratio.The best of equilibrium swelling factors for P-PTX-SRM sustained release membrane were 1%dilute acetic acid, 1h crosslinking time, 1 ∶100 crosslinking ratio; the two sustained release membranes had bursting diaphragm part and sustained release part in vitro, but burst rate of PTX-Suc-HECTS was lower than P-PTX-SRM (P<0.05) , and there was no statistical difference between the release parts, (P>0.05) .The higher crosslinking ratio, the less drug release in burst release stage in 48 h, and more drug release in sustained release stage in unit time.Conclusion PTX-Suc-HECTS sustained release membrane and P-PTX-SRM sustained release membrane have good sustained-release characteristics, P-PTX-SRM has the advantages of simple preparation process, short preparation time and saving experiment time, so it can be a preferred method to prepare the chitosan membrane.
- Chitosan sustain film,
- PTX,
- Drug,
- Methods

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References(16)

References

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