高血压患者血清血小板衍生生长因子-B与颈动脉IMT的相关性

Heng Xu Hua; Bao Xiao Hong; Zou Jian Jie; Li Chang Long; Tang Jie; Liu Ming Chun; Ni Huan Juan

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Article Navigation > Journal of Kunming Medical University > 2017 > 38(01): 103-105

Heng Xu Hua , Bao Xiao Hong , Zou Jian Jie , Li Chang Long , Tang Jie , Liu Ming Chun , Ni Huan Juan . 高血压患者血清血小板衍生生长因子-B与颈动脉IMT的相关性[J]. Journal of Kunming Medical University, 2017, 38(01): 103-105.

Citation:

Heng Xu Hua , Bao Xiao Hong , Zou Jian Jie , Li Chang Long , Tang Jie , Liu Ming Chun , Ni Huan Juan . 高血压患者血清血小板衍生生长因子-B与颈动脉IMT的相关性[J]. Journal of Kunming Medical University, 2017, 38(01): 103-105.

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高血压患者血清血小板衍生生长因子-B与颈动脉IMT的相关性

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基金：四川省医学会施慧达科研基金资助项目 (SHD13-08);

Received Date: 2016-08-30

Abstract

Abstract

Objective To study the correlation between the serum levels of platelet-derived growth factor-BB and carotid artery intima-media thickness in patients with essential hypertension． Methods Ninety essential hypertension patients without medication intake and other diseases were examined or blood and carotid artery color Doppler ultrasonogra．The serum levels of PDGF-BB were measured using ELISA．Carotid artery intima-media thickness was measured using color Doppler ultrasonogra．And， they was analyzed by linear correlation． Results The systolic blood pressure was 150.16±9.18 mmHg，diastolic blood pressure was 99.92± 6.32 mmHg，carotid artery color Doppler ultrasonogra was 0.78±0.43 mm，The serum levels of PDGF-BB was 25.78 ±12.76 ng/mL．The serum level of PDGF-BB was moderately positively correlated with carotid artery intima-media thickness （ r ＝0.483， P ＝0.000， P ＜0.001）． Conclusion The serum level of PDGF-BB is moderately positively correlated with carotid artery intima-media thickness in patients with essential hypertension．
- Platelet-derived growth factor-BB,
- Carotid artery intima-media thickness,
- Hypertension

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References(13)

References

[1]	[1]CUI Y, SUN Y W, LIN H S, et al.Platelet-derived growth factor-BB induces matrix metalloproteinase-2 expression and rat vascular smooth muscle cell migration via ROCK and ERK/p38MAPK pathways[J].Mol Cell Biochem, 2014, 393 (1-2) :255-263.
[2]	[2]RUBIN K, TINGSTRO M A, HANSSON G K, et al.Induction of B-type receptors for platelet-derived growth factor in vascular inflammation:possible implications for development of vascular proliferative lesions[J].Lancet, 1988, 1 (8599) :1353-1356.
[3]	[3]World Health Organization-International Society of Hypertension.1999 World Health Organization-International society of hypertension guidelines for the management of hypertension.Guidelines subcommittee[J].J Hypertens, 1999, 17 (2) :151-183.
[4]中国高血压防治指南修订委员会.中国高血压防治指南2010[J].中华高血压杂志, 2011, 19 (8) :701-743.
[5]	[5]CELERMAJER DS1, SORENSEN K E, GOOCH V M, et al.Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis[J].Lancet, 1992, 340 (8828) :1111-1115.
[6]	[6]OGAWA A, FIRTH A L, SMITH K A, et al.PDGF enhances store-operated Ca2+entry by upregulating STIM1/Orai1 via activation of Akt/m TOR in human pulmonary arterial smooth muscle cells[J].Am J Physiol Cell Physiol, 2012, 302 (2) :C405-411.
[7]	[7]GE X, CHEN S, LIU M, et al.Evodiamine attenuates PDGF-BB-induced migration of rat vascular smooth muscle cells through activating PPARγ[J].Int J Mol Sci, 2015, 16 (12) :28180-28193.
[8]	[8]LI D, MA S, YANG Y, et al.BTEB2 knockdown suppresses neointimal hyperplasia in a rat artery balloon injury model[J].Mol Med Report, 2011, 4 (3) :413-417.
[9]路雅茹.血小板衍生生长因子-BB与经皮冠状动脉介入术后再狭窄的相关性研究[D].天津:天津医科大学硕士论文, 2012.
[10]	[10]NAKAGAWA M, NARUKO T, IKURA Y, et al.A Decline in platelet activation and inflammatory cell infiltration is associated with the phenotypic redifferentiation of neointimal smooth muscle cells after bare-metal stent implantation in acute coronary syndrome[J].J Atheroscler Thromb, 2010, 17 (7) :675-687.
[11]	[11]NAVARRO-SOBRINO M, ROSELL A, HERNANDEZGUILLAMON M, et al.A large screening of angiogenesis biomarkers and their association with neurological outcome after ischemic stroke[J].Atherosclerosis, 2011, 216 (1) :205-211.
[12]胡启程, 孙文悦, 崔顺锦.动脉粥样硬化患者血清血小板源性生长因子的变化及氨氯地平对其的影响[J].中国老年学杂志, 2012, 32 (24) :5534-5535.
[13]	[13]MORRISON B W.Biotechnology and translational medicine[J].Clin Transl Sci, 2016, 9 (3) :125-127.

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