Progress on DNA Methylation of OPRM1 Gene in Substance Dependence

Yang Xiao Pei; Jiang Yan Ling; Ruan Ye; Zhang Shou Xun; Zhao Fei; Zhang Nin; Xia Sheng; Zhong Shu Rong

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Yang Xiao Pei , Jiang Yan Ling , Ruan Ye , Zhang Shou Xun , Zhao Fei , Zhang Nin , Xia Sheng , Zhong Shu Rong . Progress on DNA Methylation of OPRM1 Gene in Substance Dependence[J]. Journal of Kunming Medical University, 2017, 38(01): 125-128.

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Yang Xiao Pei , Jiang Yan Ling , Ruan Ye , Zhang Shou Xun , Zhao Fei , Zhang Nin , Xia Sheng , Zhong Shu Rong . Progress on DNA Methylation of OPRM1 Gene in Substance Dependence[J]. Journal of Kunming Medical University, 2017, 38(01): 125-128.

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Progress on DNA Methylation of OPRM1 Gene in Substance Dependence

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基金：国家自然科学基金资助项目 (81660232、81000577); 云南省科技厅-昆明医科大学联合专项基金资助项目 (2015FB011); 昆明医科大学大学生创新性试验计划项目 (CX201654); 云南省大学生创新创业训练计划项目 (601162023);

Received Date: 2016-10-10

Abstract

Abstract

Substance dependence mainly refers to the behavior of an individual who is strongly or repeatedly craving a drug abuse.Though psychologically aware that often or repeated doses of the substance lead to adverse consequences, but one still cannot control his own behavior.Often used substances are wine, heroin, ecstasy, K powder, methamphetamine and marijuana, etc.Regulation and control of substance addiction is by interwoven constitute of the society, environment, biology and other factors.The biological factors mainly work through the action of a drug on the central nervous system, resulting in a strong reward effect.The OPRM1 gene encoding mu opioid receptors plays a bridge role Regulation and control mode of substance addiction is by interwoven constitute of the society, environment, biology and other factors.Researches have shown that methylation of OPRM1 promoter can increase the risk of alcohol dependence syndrome and other drug dependence.This paper makes a review on the correlation between DNA methylation of OPRM1 gene and substance dependence.
- Substance dependence,
- OPRM1 gene,
- DNA methylation

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References(24)

References

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