Clinical Significance of Examination of Pretreatment Peripheral Blood HPV16E6 mRNA and CK19 mRNA in Cervical Cancer Patients

Yang Lin Lin; Wang Wei; Zhang Lei; Zhang Hong Ping; Yang Hong Ying

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Yang Lin Lin , Wang Wei , Zhang Lei , Zhang Hong Ping , Yang Hong Ying . Clinical Significance of Examination of Pretreatment Peripheral Blood HPV16E6 mRNA and CK19 mRNA in Cervical Cancer Patients[J]. Journal of Kunming Medical University, 2017, 38(01): 23-26.

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Yang Lin Lin , Wang Wei , Zhang Lei , Zhang Hong Ping , Yang Hong Ying . Clinical Significance of Examination of Pretreatment Peripheral Blood HPV16E6 mRNA and CK19 mRNA in Cervical Cancer Patients[J]. Journal of Kunming Medical University, 2017, 38(01): 23-26.

Citation:

Yang Lin Lin , Wang Wei , Zhang Lei , Zhang Hong Ping , Yang Hong Ying . Clinical Significance of Examination of Pretreatment Peripheral Blood HPV16E6 mRNA and CK19 mRNA in Cervical Cancer Patients[J]. Journal of Kunming Medical University, 2017, 38(01): 23-26.

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Clinical Significance of Examination of Pretreatment Peripheral Blood HPV16E6 mRNA and CK19 mRNA in Cervical Cancer Patients

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB168);

Received Date: 2016-09-20

Abstract

Abstract

Objective To investigate the significance of pretreatment peripheral blood HPV16E6m RNA and CK19m RNA in diagnosis and their correlations to the clinicopathologic features of cervical carcinoma.Methods One hundred cervical carcinoma patients underwent pretreatment peripheral blood HPV16E6m RNA and CK19m RNA evaluation;40 healthy women were subjected as control.The specificity and sensitivity of HPV16E6m RNA and CK19m RNA as diagnostic indexes were analyzed; their correlations to clinicopathologic features were investigated.Results The specificity of HPV16E6m RNA and CK19m RNA in the diagnosis of cervical cancer were 97.5%.The sensitivity of HPV16E6m RNA and CK19m RNA in the diagnosis of pre treatment were 15% and39%, respectively and the difference was statistically significant (P <0.05) .HPV16E6m RNA elevation was associated with clinical stage (P= 0.012) and pelvic lymph node metastasis (P=0.026) . CK19m RNA was associated with deep muscular invasion (P=0.031) and pelvic lymph node metastasis (P=0.027) .Conclusion Peripheral blood HPV16E6m RNA and CK19m RNA are the valuable tumor markers of cervical cancer.The value of CK19m RNA in the diagnosis of cervical cancer is better than that of HPV16E6m RNA.
- Cervical neoplasm,
- HPV16E6m RNA,
- CK19m RNA,
- Peripheral blood

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References(15)

References

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