Expression of Serum VEGF, MMP-9 in Eldly Patients with Advanced NSCLC in Hypercoagulative State

Liu Kun; Zhu Ying; Dong Hui; Yang Yong; Chen Xi

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Liu Kun , Zhu Ying , Dong Hui , Yang Yong , Chen Xi . Expression of Serum VEGF, MMP-9 in Eldly Patients with Advanced NSCLC in Hypercoagulative State[J]. Journal of Kunming Medical University, 2017, 38(01): 46-50.

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Liu Kun , Zhu Ying , Dong Hui , Yang Yong , Chen Xi . Expression of Serum VEGF, MMP-9 in Eldly Patients with Advanced NSCLC in Hypercoagulative State[J]. Journal of Kunming Medical University, 2017, 38(01): 46-50.

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Expression of Serum VEGF, MMP-9 in Eldly Patients with Advanced NSCLC in Hypercoagulative State

Liu Kun ¹,
Zhu Ying ¹,
Dong Hui ²,
Yang Yong ³,
Chen Xi ²

Funds:

基金：云南省卫计委内设机构基金资助项目 (2014NS026);

Received Date: 2016-09-15

Abstract

Abstract

Objective To investigate the expression and significance of serum VEGF (vascular endothelial growth factor) and MMP-9 (matrix metalloprotoinase-9) in eldly patients with advanced NSCLC (non-small cell lung cancer) in hypercoagulative state.Methods Serum VEGF and MMP-9 were detected separately by ELISA (enzyme-linked immunosorbent assay) in 30 specimens of the eldly advanced NSCLC patients with hypercoagulative state and without hypercoagulative state.Results The expression level serum VEGF and MMP-9 was 536±103pg/m L and 474±76 ng/m L in the eldly advanced NSCLC patients with hypercoagulative state;which were higher than that in without hypercoagulative samples (433±74 pg/m L and 362±43 ng/m L) (P<0.05) .The higher expression of serum VEGF in the elder advanced NSCLC patients with hypercoagulative was positively correlated with the higher expression of MMP-9 (r=0.478) P<0.05, and which was correlated with the age, the clinical TNM stage and the number of accompanying disease (P<0.05) .Conclusion VEGF and MMP-9 are highly expressed in the eldly advanced NSCLC patients in hypercoagulative state, further confirming that hypercoagulative states to some extent may promote the invasion and metastasis of elderly patients with advanced lung cancer.

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References(22)

References

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