Effects of Goal-directed Fluid Therapy with Different Ratios of Lactated Ringer's/6% Hydroxyethyl Starch on Cogulation Function in Hemorrhagic Shock Dogs

Tao Jian Ping; Qu Qi Cai; Zhou Chen; Si Yong Yu; Yang Jia Ju; Zhang Jun Hui; Wan Lin Jun

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Tao Jian Ping , Qu Qi Cai , Zhou Chen , Si Yong Yu , Yang Jia Ju , Zhang Jun Hui , Wan Lin Jun . Effects of Goal-directed Fluid Therapy with Different Ratios of Lactated Ringer's/6% Hydroxyethyl Starch on Cogulation Function in Hemorrhagic Shock Dogs[J]. Journal of Kunming Medical University, 2017, 38(01): 51-56.

Citation:

Tao Jian Ping , Qu Qi Cai , Zhou Chen , Si Yong Yu , Yang Jia Ju , Zhang Jun Hui , Wan Lin Jun . Effects of Goal-directed Fluid Therapy with Different Ratios of Lactated Ringer's/6% Hydroxyethyl Starch on Cogulation Function in Hemorrhagic Shock Dogs[J]. Journal of Kunming Medical University, 2017, 38(01): 51-56.

Citation:

Tao Jian Ping , Qu Qi Cai , Zhou Chen , Si Yong Yu , Yang Jia Ju , Zhang Jun Hui , Wan Lin Jun . Effects of Goal-directed Fluid Therapy with Different Ratios of Lactated Ringer's/6% Hydroxyethyl Starch on Cogulation Function in Hemorrhagic Shock Dogs[J]. Journal of Kunming Medical University, 2017, 38(01): 51-56.

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Effects of Goal-directed Fluid Therapy with Different Ratios of Lactated Ringer's/6% Hydroxyethyl Starch on Cogulation Function in Hemorrhagic Shock Dogs

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基金：国家自然科学基金资助项目 (81060033); 云南省教育厅科学研究基金资助项目 (2010Z030); 云南省卫生厅学科带头人培养计划基金资助项目 (D-201213);

Received Date: 2016-10-12

Abstract

Abstract

Objective To investigate the effects of goal-directed fluid therapy with different ratios of Lactated Ringer's (LR) / Hydroxyethyl Starch (HES) on coagulation function in hemorrhagic shock dogs.Methods 48 healthy beagle dogs were randomly assigned to six groups (n=8) :sham group, 3∶1 group, 2∶1group, 1∶1 group, 1∶2 and 1∶3 group.Sham group (S group) just received endotracheal incubation.While3∶1 group, 2∶1 group, 1∶1 group, 1∶2 group and 1∶3 group were regarded as treatment groups.These treatment groups were administrated hemorrhagic shock model with bleeding and then resuscitated with goal-directedfluid therapy according to different LR/HES ratios: 3 ∶1, 2 ∶1, 1 ∶1, 1 ∶2 and 1 ∶3.Targeted goal of resuscitation is stroke volume variation (SVV) below 10%, a fluid bolus 2 m L/kg of different ratios was infused within 5 min when SVV exceed 10%.Autologous blood was administrated and the hemoglobin was maintained between 10 to 11 g/d L in treatment groups.The coagulation function test (PT, APTT, TT, and Fib) was measured at baseline (T0) , 1 h after shock (T1) , 2 h after resuscitation (T2) and 4 h after resuscitation (T4) .After 4 hours of fluid resuscitation, the total amounts of fluid (the LR amounts plus the HES amounts) and the urine output were recorded.Results There was no significant statistical difference in coagulation parameters (PT, APTT, TT, and Fib) in all groups at all time points.The HES amounts of the 1∶3 and 1∶2 groups were more than the 3∶1 group;the LR amounts, the total amounts of fluid, and the urine output in the 1∶3 and 1∶2groups were lower than in the 3∶1 group.Conclusion Different LR/HES (3∶1, 2∶1, 1∶1, 1∶2 and 1∶3.) ratios' goal-directed fluid therapy have no effect on the coagulation function of hemorrhagic shock dogs.
- Goal-directed fluid therapy,
- Hypovolemic shock,
- Coagulation

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References(18)

References

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