Effect of Taking-off Joint Gout Stone Operation on the Serum Uric Acid of Gout Patients

Objective To investigatethe the effect of taking-off gout stone in different body parts on the level of serum uric acid of gout patients through retrospective anlysis.Methods We selected 72 gout patients admitted to Yunnan TCM hospital to get rid of the joint gout stones by taking-off gout stone operation, met the inclusion criteria and comleted the follow-up.According to the operation location and the part with most gout stones, the enrolled patients were divided into 2 groups:35 cases in knee joint group (35cases) and 37 cases in other-joint group.Before operation, 2 weeks later and 3 weeks after operation, patients in the two groups received the serum uric acid tests.The two-sample T test was used to analyze the s UA difference between two groups before operation and the relationship between s UA level and gout stone location was investigated.The s UA levels of patients in two groups were retested 2 weeks and 8 weeks after operation, and the two-sample T test was used to analyze the short-term and long-term effect of operation on s UA levels, and compare the difference in the s UA level of patients between two groups at 2 weeks and 8 weeks after operation.Results (1) Compared with the other joint group, the s UA of knee joint group at 1 day before operation was relatively higher, and the difference had statisticalsignificance (P<0.05) .There was no significant difference in the s UA levels of patients 2 weeks after operation between two groups (P=0.0534) .Compared with the other joint group, the s UA of knee joint group at 8 weeks after operation was significantly lower, and the difference had statistical significance (P<0.05) . (2) Compared with 1 day before operation, the s UA level of patients in knee joint group at 2 weeks and 8 weeks after operation was significantly lower, and the difference had statistical significance (P<0.01) .There was no significant difference in the s UA levels of patients in other joint group between 2 weeks after operation adn 1 day before operation (P>0.05) .Compared with 1 day before operation, the s UA level of patients in other joint group at 8 weeks after operation was significantly lower, and the difference had statistical significance (P<0.01) .Conclusion For the gout stone in knee joint, taking off and getting rid of them might be necessary in lowering the s UA and protecting knee joint.However, for the gout stone in other joints, early taking off gout stone can't stop the redeposition of urate crystal, so it may be proper to take off the gout stone before the occurrence of irreversible joint injury.