Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration

Wang Yu; Miao Wen Qing; Guang Xue Feng; Yang Jun; Zhang Yi Hong; Tian Qing; Duan Hui Xian; Wang Yan

Volume 38 Issue 04

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Wang Yu , Miao Wen Qing , Guang Xue Feng , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Wang Yan . Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration[J]. Journal of Kunming Medical University, 2017, 38(04): 127-131.

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Wang Yu , Miao Wen Qing , Guang Xue Feng , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Wang Yan . Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration[J]. Journal of Kunming Medical University, 2017, 38(04): 127-131.

Citation:

Wang Yu , Miao Wen Qing , Guang Xue Feng , Yang Jun , Zhang Yi Hong , Tian Qing , Duan Hui Xian , Wang Yan . Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration[J]. Journal of Kunming Medical University, 2017, 38(04): 127-131.

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Prediction of the Severity of Coronary Artery Disease by Plasma FKN Concentration

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基金：昆明市科技局科研基金资助项目(2016-1-S-06193);

Received Date: 2016-11-03

Abstract

Abstract

Objective To investigate the value of the plasma FKN concention in prediction of the severity of coronary heart disease(CHD). Methods In this study, 89 patients who underwent coronary intervention therapy in our hospital between July and December 2015 were sequentially selected. Patients were divide into 3 groups according to the result of Coronary angiography, including group B: 43 patients of acute myocardial infarction(AMI) or Coronary Severe lesions;group B1: 26 patients of single mild Coronary lesions;group N: 20 patients with no Coronary heart disease(CHD),excluded by normal Coronary angiography result. The baseline clinical data of all 89 patients were collected. Enzyme-linked immunosorbent method was used to test the FKN level. SPSS 20.0Statistical software was used for data analysis. Results The FKN levels of patients were decreased in all 3 groups:group B> group B1>group N, with significant differencesbetween the three groups(P <0.000). There was a positive correlation between FKN and Gensini score or hs c Tn T(P<0.05). The area under the curve(AUC) of the receiver operating characteristic(ROC) curves was 0.784, the diagnostic reference value for Coronary heart disease(CHD) acute myocardial infarction was 1.996 in this sudy. Conclusions The plasma FKN levels are positively correlated to the severity of coronary lesion. The specificity and sensitivity of plasma FKN level for coronary heart disease(CHD) diagnosis is similar to CTn T. The plasma FKN levels can provide evidence of lesion severity of Coronary heart disease(CHD).
- FKN,
- Coronary heart disease,
- Acute myocardial infarction

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