The Pathological Changes of Occupational Lung Cancer in Yunnan Gejiu's Tin Miners and the Therapy and Survival Analysis of 97 Lung Squamous Carcinoma

Wang Jia Zhu; Diao Xian Min; Kang Zhen; Chang Run Sheng; Lei Zi Fa; Sun Li; Wang Zhao Min; Cao E; Li Wen Hui

Volume 38 Issue 04

Turn off MathJax

Article Contents

Abstract

References

Relative Articles

Article Navigation > Journal of Kunming Medical University > 2017 > 38(04): 52-57

Wang Jia Zhu , Diao Xian Min , Kang Zhen , Chang Run Sheng , Lei Zi Fa , Sun Li , Wang Zhao Min , Cao E , Li Wen Hui . The Pathological Changes of Occupational Lung Cancer in Yunnan Gejiu's Tin Miners and the Therapy and Survival Analysis of 97 Lung Squamous Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(04): 52-57.

Citation:

Wang Jia Zhu , Diao Xian Min , Kang Zhen , Chang Run Sheng , Lei Zi Fa , Sun Li , Wang Zhao Min , Cao E , Li Wen Hui . The Pathological Changes of Occupational Lung Cancer in Yunnan Gejiu's Tin Miners and the Therapy and Survival Analysis of 97 Lung Squamous Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(04): 52-57.

Citation:

Wang Jia Zhu , Diao Xian Min , Kang Zhen , Chang Run Sheng , Lei Zi Fa , Sun Li , Wang Zhao Min , Cao E , Li Wen Hui . The Pathological Changes of Occupational Lung Cancer in Yunnan Gejiu's Tin Miners and the Therapy and Survival Analysis of 97 Lung Squamous Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(04): 52-57.

PDF( 200 KB)

The Pathological Changes of Occupational Lung Cancer in Yunnan Gejiu's Tin Miners and the Therapy and Survival Analysis of 97 Lung Squamous Carcinoma

Funds:

基金：国家自然科学基金资助项目(81560488,81660504); 云南省教育厅科学研究基金重点资助项目(2015Z090);

Received Date: 2016-12-19

Abstract

Abstract

Objective To explore the incidence trends for different pathological types of occupational lung cancer in tin miners in Gejiu city of Yunnan province and analyze the treatment and efficacy of lung squamous cell carcinoma. Methods A retrospective study was carried out to review the pathological data of 210 patients who diagnosed occupational lung cancer in tin miners at the 3rd People's Hospital of Honghe Autonomous from January2005 to December 2012.The treatment patterns, overall survival(OS) and prognostic factors of 97 patients with squamous cell lung carcinoma were assessed from diagnosis until death or last follow-up. The Kaplan-Meier method was used to evaluate the overall survival. Log-rank test(for univariate prognostic analysis) and Cox regression analysis(for multivariate prognostic analysis) were performed in the 97 squamous cell lung carcinoma patients.Results The percentage distribution of pathological categories of all the 210 occupational lung cancer patients of tin miners was as follows: squamous cell lung carcinoma 46.2%, adenocarcinoma(AC) 31%, small cell lung carcinoma 19%, and the other 3.8%. Of the 97 patients of occupational squamous cell lung carcinoma of tin miners,the 1-, 2-, and 3-year OS rates of TMN stage I-II patients were 83.3%, 74.8%, 64.8%, stage Ⅲa-Ⅲb were29.8%,6.8 %,3.4% and stage IV were 9.8%,2.4%,0%(p=0.000). Multivariate analysis showed that KPS score,TNM stage and treatment patterns were the independent prognostic factors of overall survival in patients with occupational squamous cell lung carcinoma. Conclusions In the occupational lung carcinoma of tin miners in Gejiu, Yunnan before 2005, the proportion of squamous cell carcinoma(SCC) decreased and the proportion of adenocarcinoma corresponding increased. In occupational squamous cell lung carcinoma patients, the prognosis of TMN stage I/II was similar to the patients with NSCLC at home and aboard. While for patients of stage III and IV,the prognosis was worse. The KPS scoring, TNM staging and therapy methods are the independent prognostic factors for occupational squamous cell lung carcinoma patients.
- Occupational lung cancer,
- Pathological type,
- Squamous cell carcinoma,
- Therapy,
- Oerall survival,
- Prognostic factor

FullText(HTML)

References(14)

References

[1]	[1]EDWARD C,HELPERIN,CARLOS A,et al.Perez and brady,s principles ang practice of radiation oncology,fifth edition[M].Philadelphia:Lippincott Williams Wilkins,USA,2012:1188-1223.
[2]殷蔚伯,余子豪,徐国镇,等.肿瘤放射治疗学[M].第4版.北京:中国协和医科大学出版社,2007:578-608.
[3]姚树祥,晋萍,范亚光,等.云南锡矿工人肺癌高发的流行病学调查(1954-2002年)[J].环境与职业医学,2007,24(5):465-468.
[4]范亚光,乔友林.云锡矿工肺癌的筛查与随访研究[D].北京:协和医科大学博士研究生论文,2007.
[5]李新,常润生,石云,等.2261例云锡矿工肺癌临床分析[J].中国肺癌杂志,2001,45(4):70-72.
[6]范亚光,姜勇,常润生,等.职业高危人群肺癌病例胸部X线片和痰细胞学筛查结果分析[J].中国肺癌杂志,2007,10(2):461-463.
[7]	[7]ERIC K,HANSEN M D,MACK ROACH,et al.Handbook of evidence-based radiation oncology[M].2nd Edition.New york:Springer Science+Business Media,LLC,2010:247-248.
[8]	[8]MAEDA H,MATSUMURA A,et al.Adenosquamouse carcinoma of the lung:Surgical results as compared with squamouse cell and adenocarcinoma cases[J].Eur J Cardiothorac Surg,2012,41(2):357-361.
[9]	[9]CHRISTOPHER M,BOOTH M D.Time to adjuvant chemotherapy and survival in non-small cell lung cancer[J].Cancer,2013,3(15):1243-1250.
[10]	[10]PERER GOLDSTRAW,DAVID BALL,JAMES R JEtt,et al.Non-small cell lung cancer[J].Lancet,2011,378(9804):1272-1240.
[11]彭红,马美丽,韩宝惠,等.1742例Ⅳ期非小细胞肺癌的预后分析[J].中国肺癌杂志,2011,4(04):362-366.
[12]韦静妮,程雄飞,谢丛华,等.150例老年非小细胞肺癌临床特点与预后因素分析[J].武汉大学学报(医学版).2013,34(3):372-376.
[13]孙世荃.云锡矿工肺癌病因学研究概况[J].中华放射医学与防护杂志,1998,18(5):295-298.
[14]刘晓美.云锡矿矿工肺癌危险因素的队列研究[J].中国肺癌杂志,2013,16(42):184-190.

Relative Articles(20)

Relative Articles

[1]	Haixia GU, Jiangli PENG, anxin CHEN, Rui YIN, qiqi XIAO, Jie CHEN. Clinical Characteristics and Prognostic Analysis of Maintenance Hemodialysis Patients With Initial Treatment Tuberculosis. Journal of Kunming Medical University, 2025, 46(): 1-7.
[2]	Yichao JIN, Xiaochuan WANG, Chunping AO, Liangheng XU. Pruritus in Keloid：Pathogenesis and Treatments. Journal of Kunming Medical University, 2024, 45(12): 167-171. doi: 10.12259/j.issn.2095-610X.S20241224
[3]	Hongxiu YANG, Zhongshan ZHU. Effect of HPRT1 Gene Expression on Overall Survival of Patients with Lung Adenocarcinoma. Journal of Kunming Medical University, 2024, 45(8): 17-23. doi: 10.12259/j.issn.2095-610X.S20240803
[4]	Xi-hua ZHANG, Tao JIA, Wei-tao LIU, Qing WAN, Jin-feng WANG, Xi LI, Jin-song LIU. The Pathogenesis and Current Therapy of Hip Ankylosis. Journal of Kunming Medical University, 2021, 42(9): 144-148. doi: 10.12259/j.issn.2095-610X.S20210902
[5]	Ye YUAN, Jian CHANG, Dong-bo LIU, Bao-cheng JIANG. Lymph Node Metastasis of Mixed Early Gastric Cancer and Its Influence on Prognosis. Journal of Kunming Medical University, 2021, 42(3): 79-83. doi: 10.12259/j.issn.2095-610X.S20210321
[6]	Jiang-pin XU, Jun MA, Nan XIE, Qian WU, Fan CAO, Rong-ji YAN, Hua WANG. Clinical Application Value of Ultrasound in the Diagnosis of Acute Appendicitis. Journal of Kunming Medical University, 2020, 41(11): 78-82. doi: 10.12259/j.issn.2095-610X.S20201118
[7]	Li Ming . The Current Situation of Research and Treatment on Male Breast Cancer. Journal of Kunming Medical University,
[8]	Yang Xiao Yun . The Clinical Diagnosis and Treatment of 143 Cases of Hodgkin's Lymphoma. Journal of Kunming Medical University,
[9]	Lin Jin . . Journal of Kunming Medical University,
[10]	Yuan Hua Yuan . . Journal of Kunming Medical University,
[11]	Zhang Lei . . Journal of Kunming Medical University,
[12]	Wan Yong . . Journal of Kunming Medical University,
[13]	Zhang Meng Si . . Journal of Kunming Medical University,
[14]	Zhang Yi . . Journal of Kunming Medical University,
[15]	Yan Bing . . Journal of Kunming Medical University,
[16]	Fang Ke Wei . . Journal of Kunming Medical University,
[17]	Yang Peng . . Journal of Kunming Medical University,
[18]	Li Xian Li . . Journal of Kunming Medical University,
[19]	Zhan Hui . Treating Complex Upper Urinary Calculi With Different Type of Channel of Percutaneous Renal Fistula. Journal of Kunming Medical University,
[20]	Xia Yao Xiong . . Journal of Kunming Medical University,