HSF2 Promotes Heat Shock Protein Expression in Lung Cancer

Fan Min Juan; Zhong Yun Hua; Shen Wen; Yuan Kai Fen; Zhao Guo Hou; Wang Shu Kun; Wen Lin Qiao

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Fan Min Juan , Zhong Yun Hua , Shen Wen , Yuan Kai Fen , Zhao Guo Hou , Wang Shu Kun , Wen Lin Qiao . HSF2 Promotes Heat Shock Protein Expression in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 108-112.

Citation:

Fan Min Juan , Zhong Yun Hua , Shen Wen , Yuan Kai Fen , Zhao Guo Hou , Wang Shu Kun , Wen Lin Qiao . HSF2 Promotes Heat Shock Protein Expression in Lung Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 108-112.

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HSF2 Promotes Heat Shock Protein Expression in Lung Cancer

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB197); 云南省教育厅科学研究基金资助项目 (2014Z066);

Received Date: 2017-03-14

Abstract

Abstract

Objective To explore the influence of HSF2 on occurrence of lung cancer and tumor cell proliferation by promoting HSP's expression. Me thods We selected the para-carcinoma tissue from patients with lung cancer, then constructed the eukaryoticvector of HSF2 overexpression, then respectively transfected into BEAS-2B and A549, in order to exam its influence on cell proliferation and HSP expression, and we co-transfected the si RNA of HSP27 and HSP90 while the transfection of p IRES2-EGFP-HSF2, in order to exam the influence on cell proliferation. Re s ults The overexpression of HSF2 may increase BEAS-2B, improve the A549 proliferation speed (P<0.01) and the expressions of HSP27, HSP90. The co-transfected si RNA of HSP27 and HSP90 may equally recede the cell proliferations of BEAS-2B and A549 induced by HSF2 (P <0.01) .Conclus ion The cell proliferation of lung cancer promoted by HSF2 may possibly be achieved through promoting the expression of HSP.
- Lung Cancer,
- HSF2,
- Heat Shock Protein,
- BEAS-2B,
- A549

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References(14)

References

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