A Meta-analysis of rh-endostatin Combined with Chemotherapy in the Treatment of Advanced Breast Cancer

Feng Lin Sen; Li Jing Juan; Wang Yu Feng

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Feng Lin Sen , Li Jing Juan , Wang Yu Feng . A Meta-analysis of rh-endostatin Combined with Chemotherapy in the Treatment of Advanced Breast Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 118-123.

Citation:

Feng Lin Sen , Li Jing Juan , Wang Yu Feng . A Meta-analysis of rh-endostatin Combined with Chemotherapy in the Treatment of Advanced Breast Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 118-123.

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A Meta-analysis of rh-endostatin Combined with Chemotherapy in the Treatment of Advanced Breast Cancer

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基金：中国临床肿瘤学会科研基金资助项目 (Y-S2016-002); 云南省教育厅科学研究基金重点资助项目 (2015Z089);

Received Date: 2017-02-13

Abstract

Abstract

Objective To evaluate the clinical efficacy and adverse effects induced by rh-endostatin (rh-ES) combined with chemotherapy in the treatment of advanced breast cancer. Methods The Pubmed, Embase, Cochrane Library, Spriner, CNKI, VIP, Wangfang Data, CBM were searched for literature up to April 2016. We searched randomized controlled clinical trials of rh-endostatin combined with chemotherapy in the treatment of advanced breast cancer and judged whether the trials met the inclusive criteria. Then Meta analysis was performed by using Rev Man v5.3 software after extracting useful data. Re s ults Six researches with 346 patients were included according to the inclusive criteria. Meta analysis demonstrated that rh-endostatin combined with chemotherapy had statistically significant increase over chemotherapy alone in terms of objective respond rate (RR=1.41, 95% CI: 1.13-1.77) or disease control rate (RR=1.21, 95% CI: 1.08-1.35) , and had statistically significant benefit in progression of disease ( RR=0.49, 95% CI: 0.32-0.75) . The incidence rates of leukopenia, thrombocytopenia and gastrointestinal reaction were no significant difference between two groups.Conclus ions Rh-endostatin combined with chemotherapy may have more meaningful clinical improvement in objective respond rate, disease control rate and progression of disease. The combination therapy had not added the adverse effects rates significantly.
- Breast neoplasms,
- Rh-endostatin,
- Clinical efficacy,
- Adverse effects,
- Meta analysis

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References(22)

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