Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance

Zhang Jin Tian; Yu Xue Ying; Xie Qun

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Zhang Jin Tian , Yu Xue Ying , Xie Qun . Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2017, 38(06): 28-31.

Citation:

Zhang Jin Tian , Yu Xue Ying , Xie Qun . Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2017, 38(06): 28-31.

Zhang Jin Tian , Yu Xue Ying , Xie Qun . Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2017, 38(06): 28-31.

Citation:

Zhang Jin Tian , Yu Xue Ying , Xie Qun . Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance[J]. Journal of Kunming Medical University, 2017, 38(06): 28-31.

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Expression of Tiam1 and Fascin in Esophagus Squamous Carcinoma and Its Clinical Significance

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基金：福建省教育厅科研基金资助项目 (JA15442); 福建省大学生创新创业计划资助项目 (201611498036);

Received Date: 2017-03-04

Abstract

Abstract

Objective To investigate the clinical significance of Tiam1 and Fascin protein expression in esophagus squamous carcinoma.Me thods Immunohistochemical SP method was used to detect Tiam1, Fascin protein in esophageal squamous carcinoma and normal esophageal tissue. Re s ults Tiam1, Fascin protein expression in esophageal squamous carcinoma tissues was significantly higher in the expression of normal esophageal tissue (P<0.05) , which was correlated with TNM stage, infiltration degree, lymphatic metastasis.Tiam1 protein expression was related to pathological grading of esophageal squamous carcinoma., and Fascin protein expression has no relation with the pathological grading of esophageal squamous carcinoma.There was close correlation between Tiam1 protein and Fascin protein (r = 0.302, P <0.01) . Conclus ions The higher expression of Tiam1 and Fascin in esophageal squamous carcinoma, are closely associated with invasion and metastasis. Tiam1 and Fascin may synergy effect in the process of esophageal squamous carcinoma. Tiam1, Fascin may become new targets in the therapy of esophagus squamous carcinoma.
- Esophagus squamous carcinoma,
- Tiam1,
- Fascin

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References(16)

References

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