非生物型人工肝技术治疗肝衰竭合并肝肾综合征

Zhang Le; Tang Li Bin; Jiang Jian Jie; Xia Jia Wei; Lv Zheng Xuan; Li Yun Zhen; Han Liu Xin; Bai Bin

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Article Navigation > Journal of Kunming Medical University > 2017 > 38(06): 36-39

Zhang Le , Tang Li Bin , Jiang Jian Jie , Xia Jia Wei , Lv Zheng Xuan , Li Yun Zhen , Han Liu Xin , Bai Bin . 非生物型人工肝技术治疗肝衰竭合并肝肾综合征[J]. Journal of Kunming Medical University, 2017, 38(06): 36-39.

Citation:

Zhang Le , Tang Li Bin , Jiang Jian Jie , Xia Jia Wei , Lv Zheng Xuan , Li Yun Zhen , Han Liu Xin , Bai Bin . 非生物型人工肝技术治疗肝衰竭合并肝肾综合征[J]. Journal of Kunming Medical University, 2017, 38(06): 36-39.

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非生物型人工肝技术治疗肝衰竭合并肝肾综合征

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基金：云南省省院共建肝病重点专科建设基金资助项目 (云卫医发〔2015〕18号); 昆明市感染性疾病血液净化中心建设基金资助项目 (昆卫办〔2016〕115号); 云南省重症医学科 (感染性疾病) 重点专科建设基金资助项目 (云卫医发〔2017〕15号);

Received Date: 2017-02-19

Abstract

Abstract

目的探讨不同类型的非生物型人工肝技术对肝衰竭合并肝肾综合征的临床疗效.方法选取2014年1月至2015年12月在昆明市第三人民医院住院的肝功能衰竭合并肝肾综合征患者60例作为研究对象, 共行人工肝治疗317人次.入院后根据治疗方案的不同分为观察组和对照组, 每组30例, 观察组给予血浆置换联合血液透析滤过 (plasma exchange+hemo-diafiltration, PE+HDF) 治疗, 对照组给予血浆置换 (plasma exchange, PE) 治疗.观察2组治疗后肝肾功能、凝血功能及电解质的变化及近期疗效.结果 (1) 治疗后, 观察组血清总胆红素、尿素氮、肌酐、钾等指标水平明显低于对照组, 差异有统计学意义 (P<0.05) ;观察组凝血酶原活动度指标明显上升, 且高于对照组, 差异有统计学意义 (P<0.05) ; (2) 在近期疗效方面, 观察组达到78.95%, 高于对照组 (50%) , 差异有统计学意义 (P<0.05) .结论相对血浆置换来说, 血浆置换联合血液透析治疗肝衰竭合并肝肾综合征方面更具优势, 能够有效改善肝肾功能及维持电解质平衡, 近期治疗有效率更高.
- Artificial liver,
- Liver failure,
- Hepatorenal syndrome,
- Clinical research

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References(10)

References

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