Zhang Le , Tang Li Bin , Jiang Jian Jie , Xia Jia Wei , Lv Zheng Xuan , Li Yun Zhen , Han Liu Xin , Bai Bin . 非生物型人工肝技术治疗肝衰竭合并肝肾综合征[J]. Journal of Kunming Medical University, 2017, 38(06): 36-39.
Citation: Zhang Le , Tang Li Bin , Jiang Jian Jie , Xia Jia Wei , Lv Zheng Xuan , Li Yun Zhen , Han Liu Xin , Bai Bin . 非生物型人工肝技术治疗肝衰竭合并肝肾综合征[J]. Journal of Kunming Medical University, 2017, 38(06): 36-39.

非生物型人工肝技术治疗肝衰竭合并肝肾综合征

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基金: 云南省省院共建肝病重点专科建设基金资助项目 (云卫医发〔2015〕18号); 昆明市感染性疾病血液净化中心建设基金资助项目 (昆卫办〔2016〕115号); 云南省重症医学科 (感染性疾病) 重点专科建设基金资助项目 (云卫医发〔2017〕15号);

  • Received Date: 2017-02-19
  • 目的 探讨不同类型的非生物型人工肝技术对肝衰竭合并肝肾综合征的临床疗效.方法 选取2014年1月至2015年12月在昆明市第三人民医院住院的肝功能衰竭合并肝肾综合征患者60例作为研究对象, 共行人工肝治疗317人次.入院后根据治疗方案的不同分为观察组和对照组, 每组30例, 观察组给予血浆置换联合血液透析滤过 (plasma exchange+hemo-diafiltration, PE+HDF) 治疗, 对照组给予血浆置换 (plasma exchange, PE) 治疗.观察2组治疗后肝肾功能、凝血功能及电解质的变化及近期疗效.结果 (1) 治疗后, 观察组血清总胆红素、尿素氮、肌酐、钾等指标水平明显低于对照组, 差异有统计学意义 (P<0.05) ;观察组凝血酶原活动度指标明显上升, 且高于对照组, 差异有统计学意义 (P<0.05) ; (2) 在近期疗效方面, 观察组达到78.95%, 高于对照组 (50%) , 差异有统计学意义 (P<0.05) .结论 相对血浆置换来说, 血浆置换联合血液透析治疗肝衰竭合并肝肾综合征方面更具优势, 能够有效改善肝肾功能及维持电解质平衡, 近期治疗有效率更高.

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  • [1] 中华医学会感染病分会肝衰竭与人工肝组, 中华医学会肝病学分会重型肝病与人工肝组.肝衰竭诊治指南 (2012年版) [J].中华临床感染病杂志, 2012, 5 (6) :321-327.
    [2]郑明华.Sherlock肝胆病学[M].北京:人民卫生出版社, 2014:205-208.
    [3]孙西照, 陈进国.血浆置换联合血液透析滤过治疗重型肝炎肝肾综合征临床观察[J].中华临床医师杂志 (电子版) , 2011, 5 (15) :4545-4546.
    [4]吕日英, 吴继周.重型肝炎患者并发肝肾综合征的危险因素[J].临床肝胆病杂志, 2012, 28 (7) :542-544.
    [5]尚佳, 曹青.肝肾综合征的诊断[J].中华肝脏病杂志, 2011, 19 (3) :165-166.
    [6]陈盛鹏, 何卫平, 胡瑾华, 等.肝肾综合征329例预后分析[J].传染病信息, 2010, 23 (2) :87-89.
    [7]高宝秀, 贺勇, 李贵星, 等.慢性重型肝炎并发肝肾综合征的相关因素分析[J].临床肝胆病杂志, 2011, 27 (7) :749-751.
    [8]段钟平.人工肝脏治疗学[M].北京:中国医药科技出版社, 2002:6.
    [9]陈幼明, 朱建芸, 李建国, 等.血浆置换联合持续性血液滤过透析对慢性重型乙型病毒性肝炎临床症状及生化指标的影响[J].新医学, 2008, 39 (1) :13-16.
    [10]
    [10]NAKAEH, YONEKAWA, NARITAK, et al.Areproinflam matory cytokine concentrations reduced by plasma exchange in patents with severe acute hepatic failure[J].Res Communmol Pathol Pharmacol, 2001, 109 (1-2) :65-72.
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