武汉地区123例冠心病患者CYP2C19基因多态性分布

Li Lin; Li Ji Yi; Wang De Zhao; Liu Wei

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Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

Citation:

Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

Citation:

Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布[J]. Journal of Kunming Medical University, 2017, 38(06): 60-63.

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武汉地区123例冠心病患者CYP2C19基因多态性分布

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基金：北京市优秀青年基金资助项目 (2011D008017000002);

Received Date: 2017-04-03

Abstract

Abstract

目的探讨武汉地区冠心病患者药物代谢酶CYP2C19基因多态性的分布.方法采用基因芯片法对123例服用氯吡格雷的无血缘关系的冠心病患者进行CYP2C19基因分型, 分析其基因型及代谢表型的分布, 并与文献报道中中国汉族人群进行比较.结果共统计发现5种基因型, 3种代谢表型;检测出快代谢型 (EM) 患者38例, 所占比例为30.9%, 检测出中间代谢型 (IM) 患者69例, 所占比例为56.1%, 检测出慢代谢型 (PM) 患者16例, 所占比例为13.0%.武汉地区冠心病患者中, CYP2C19基因代谢表型分布与文献报道无统计学意义 (P>0.05) .结论武汉地区冠心病患者中, CYP2C19基因存在多态性, 基因频率及代谢型分布频率与国内其他地区相一致.
- Coronary heart disease,
- Polymorphism of CYP2C19 gene,
- Distribution of metabolic phenotype,
- Clopidogrel

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References(20)

References

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