Laboratory Diagnosis and Correlation Analysis on Rheumatoid Arthritis Complicated with Coronary Heart Disease

Pan Li; Pan Bao Long; Li Jun E; Wu Ying Song

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(06): 82-86

Pan Li , Pan Bao Long , Li Jun E , Wu Ying Song . Laboratory Diagnosis and Correlation Analysis on Rheumatoid Arthritis Complicated with Coronary Heart Disease[J]. Journal of Kunming Medical University, 2017, 38(06): 82-86.

Citation:

Pan Li , Pan Bao Long , Li Jun E , Wu Ying Song . Laboratory Diagnosis and Correlation Analysis on Rheumatoid Arthritis Complicated with Coronary Heart Disease[J]. Journal of Kunming Medical University, 2017, 38(06): 82-86.

Citation:

PDF( 227 KB)

Laboratory Diagnosis and Correlation Analysis on Rheumatoid Arthritis Complicated with Coronary Heart Disease

Funds:

基金：云南省高层次卫生技术人才专项经费资助项目 (D-201206);

Received Date: 2017-03-14

Abstract

Abstract

Objective To investigate the diagnostic value and correlation of corresponding laboratory indexes in rheumatoid arthritis (RA) complicated with coronary heart disease (CHD) . Me thods According to gender and age, patients were divided into RA concurrent CHD group, simple RA group, simple CHD group and healthy control group, with 102 cases in each group. The Level change of RA specificity index (ESR, RF, ACCP, IL-6) and CHD specificity index (CK, CK-MB, α-HBDH, hs-Tn T, Mb) in the four groups were analyzed retrospectively, and we statistically analyzed the correlation between the two groups of specific indicators in RA complicated with CHD group. Re s ults The rate of joint deformity in RA sick group (including simple and concurrent) was significantly higher than that in non-RA group (P =0.000) , the hypertension prevalence and smoking rate in simple CHD group were significantly higher than the other three groups (P=0.016, 0.021) , there was no significant difference in BMI and TC between the four groups (P>0.05) In patients with RA complicated with CHD, the RA specificity index of ESR, RF, ACCP and IL-6, and CKD specificity index of CK, CK-MB, hs-Tn T and Mb were significantly increased (P <0.05) . ACCP was positively correlated with CK and CK-MB (P <0.05) , IL-6 was positively correlated with CK, CK-MB and Mb (P <0.05) . Conclus ion The detection of ACCP or IL-6 in RA patients can predict the incidence of RA complicated with CHD.
- Rheumatoid arthritis,
- Coronary heart disease,
- Laboratory diagnosis

FullText(HTML)

References(16)

References

[1]	[1]SOUBRIER M, BARBER CHAMOUX N, TATAR Z, et al.Cardiovascular risk in rheumatoid arthritis[J].Joint Bone Spine, 2014, 81 (4) :298-302.
[2]	[2]NAKAJIMA AYAKO.Cardiovascular diseases in rheumatoid arthritis nihon rinsho[J].Japanese journal of clinical medicine, 2016, 74 (6) :1012-1016.
[3]	[3]ALETAHA D, NEOGI T, SILMAN A T, et al.2010 Rheumatoid arthritis classification criteris:an American Collefe of Rheumatology/European League Against Rheumatism collaborative initative[J].Arthritis Rheum, 2010, 62 (9) :2569-2581.
[4] 国际心脏病学会和协会WHO命名标准化联合专题组.缺血性心脏病命名及诊断标准[J].中华心血管杂志, 1981, 9 (11) :75-76.
[5]	[5]DI W T, VERGARA F, BERTILLER E, et al.Encidence and Prevalence of Rheumatoid Arthritis in a Health Management Organization in Argentina:A 15-year Study[J].J Rheumatol, 2016, 43 (7) :1306-1311.
[6]	[6]BARBER C E, SMITH A, ESDIALE J M, et al.Best practices for cardiovascular disease prevention in rheumatoid arthritis:a systematic review of guideline recomm endations and quality indicators[J].Arthritis Care Res (Hoboken) , 2015, 67 (2) :169-179.
[7]	[7]EIRIK IKDAHL, SILVIA ROLLEFSTAD, INGE OLSEN, et al.EULAR task force recommendations on annual cardiovascular risk assessment for patients with rheumatoid arthritis:an audit of the success of implementation in rheumatology out patient clinic[J].Biomed Res Int, 2015, 18 (9) :515280.
[8]蔡辉, 常文静, 商玮.血管新生在类风湿关节炎中的作用[J].安徽医药, 2015, 19 (3) :417-421.
[9]	[9]ZHANG D, MA M, YANG Y, et al.Association between polymorphisms in IL27 and risk for CHD in a Chinese population[J].Cardiol Young, 2016, 26 (2) :237-243.
[10]	[10]HARALDSDOTTIR A, TORFADOTTIR J E, VALDIMARSDOTTIR U A, et al.Fish and fish-liver oil consumption in adolescence and midlife and risk of CHD in older women[J].Public Health Nutr, 2016, 19 (2) :318-325.
[11]周凯华, 石兴民.2型糖尿病并冠心病患者骨保护素及TGF-β1与糖代谢指标的相关性[J].昆明医科大学学报, 2014, 35 (10) :39-41.
[12]尚红, 王毓三, 申子瑜.全国临床检验操作规程[M].第四版.北京:人民卫生出版社, 2015:436.
[13]伍尚剑, 雷国大, 谭宗宪, 等.抗CCP、RF和CRP联合检测诊断类风湿性关节炎的临床价值[J].中国当代医药, 2015, 22 (9) :134-136.
[14]陶敏, 郑康超, 肖淼淼, 等.IL-6与冠心病相关性的研究进展[J].华中科技大学学报 (医学版) , 2016, 45 (5) :585-587.
[15]丁艳杰, 赵清, 王来芳, 等.类风湿患者血清颈动脉硬化与炎性因子相关性分析[J].昆明医科大学学报, 2014, 35 (4) :50-53.
[16]李从凤.超敏肌钙蛋白T (HS-TNT) 、肌酸激酶同工酶 (CK-MB) 、肌红蛋白 (Mb) 浓度监测在诊断急性心肌梗死 (AMI) 中的作用[J].心血管病防治知识, 2015, 18 (7) :44-46.

Relative Articles(20)

Relative Articles

[1]	Shuangshuang XU, Wei ZHAO, Lei JIANG, Huajiang LIU, Fang WANG, Zhisheng TAN, Likun ZHOU. Correlation Between TyG Index，MHR and Coronary Lesions，Myocardial Ischemia in Patients with Coronary Heart Disease，and the Value of Combined Detection. Journal of Kunming Medical University, 2024, 45(3): 65-71. doi: 10.12259/j.issn.2095-610X.S20240310
[2]	Wenqing MIAO, Yu WANG, Xiaoli ZHAO, Nini TIAN, Liying YOU. Analysis of Differential Gene Expression and Function in Peripheral Blood of Patients with Coronary Heart Disease and Acute Myocardial Infarction. Journal of Kunming Medical University, 2022, 43(6): 25-34. doi: 10.12259/j.issn.2095-610X.S20220614
[3]	Jing TANG, Jun-chao HUANG, Ya-fei HUANG, Ming-zhu GENG, Xiao-qin MAO, Jian-ping PU. Application of Lipoprotein-associated Phospholipase A2 in Coronary Heart Disease Patients Taking Statins. Journal of Kunming Medical University, 2021, 42(12): 6-10. doi: 10.12259/j.issn.2095-610X.S20211205
[4]	Bin LIU, Xian-gang LI, Min ZHANG, Fang ZHOU, Ren-hua LIN, Jie YANG, Liang ZHANG, Xian-kun WANG, Ya-nan PAN. Main Influencing Factors of the Second Hospitalization of Patients with Coronary Heart Disease. Journal of Kunming Medical University, 2021, 42(6): 103-109. doi: 10.12259/j.issn.2095-610X.S20210618
[5]	Dai Hai Long , Zhang Xing , Pan Yun , Feng Xiao Lan , Lu Xiang Ting , Guang Xue Feng , Yin Xiao Long . . Journal of Kunming Medical University, 2020, 41(04): 60-63.
[6]	Xu XU, Li-yong WU, Ming-li ZHOU, Guo-fu ZHU. Relationship between microRNA-146a and the Plaque Stability in Coronary Heart Disease Patients. Journal of Kunming Medical University, 2020, 41(11): 56-61. doi: 10.12259/j.issn.2095-610X.S20201119
[7]	Wang Ji Yan , Duan Yong . . Journal of Kunming Medical University, 2018, 39(12): 1-4.
[8]	Li Lin , Li Ji Yi , Wang De Zhao , Liu Wei . 武汉地区123例冠心病患者CYP2C19基因多态性分布. Journal of Kunming Medical University, 2017, 38(06): 60-63.
[9]	Gai Nan Nan , Li Guo Hui . . Journal of Kunming Medical University, 2017, 38(03): 111-114.
[10]	Pan Bao Long , Wu Ling , Pan Li , Zhang Yuan Yuan , Li Jun E , Zhan Xue Liang . Application of Related Laboratory Indexes in Early Rheumatoid Arthritis. Journal of Kunming Medical University, 2017, 38(11): 96-100.
[11]	Xiao Yi . The Clinical Effect of CDSP Treatment for Coronary Heart Disease. Journal of Kunming Medical University,
[12]	Li Wen Hua , Wei Yun Hong , Ye Ji Yun . Effect of Probiotics on Blood Lipid Metabolism of Elderly Patients with Coronary Heart Disease. Journal of Kunming Medical University, 2016, 37(12): 82-84.
[13]	Feng Yong Hong . . Journal of Kunming Medical University,
[14]	Dai Qing Yuan . . Journal of Kunming Medical University,
[15]	Li Hong Dao . . Journal of Kunming Medical University,
[16]	Yang Ping . . Journal of Kunming Medical University,
[17]	Tan Xiao Bing . . Journal of Kunming Medical University,
[18]	Zhou Kai Hua . . Journal of Kunming Medical University,
[19]	Lv Han Xian . Detection of Periodontopathogens in Subgingival Plaque of Patients with Coronary Heart Disease and Periodontitis. Journal of Kunming Medical University,
[20]	Yin Lin . . Journal of Kunming Medical University,