Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension

Li Ya Ping; Li Yong Xia; Niu Xiao Qun; Hai Bing; Cao Yu; Chai Yan Ling

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Article Navigation > Journal of Kunming Medical University > 2017 > 38(06): 92-96

Li Ya Ping , Li Yong Xia , Niu Xiao Qun , Hai Bing , Cao Yu , Chai Yan Ling . Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension[J]. Journal of Kunming Medical University, 2017, 38(06): 92-96.

Citation:

Li Ya Ping , Li Yong Xia , Niu Xiao Qun , Hai Bing , Cao Yu , Chai Yan Ling . Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension[J]. Journal of Kunming Medical University, 2017, 38(06): 92-96.

Citation:

Li Ya Ping , Li Yong Xia , Niu Xiao Qun , Hai Bing , Cao Yu , Chai Yan Ling . Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension[J]. Journal of Kunming Medical University, 2017, 38(06): 92-96.

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Correlation between Smoking and Inflammatory Factors in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicated with Pulmonary Hypertension

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2015FB052);

Received Date: 2017-04-21

Abstract

Abstract

Objective To explore the relationship between acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and pulmonary hypertension (PH) in patients with chronic obstructive pulmonary disease (COPD) . Me thods Using retrospective analysis, we collected from March 2015 to March 2016 in the department of respiratory internal medicine (ward two) in our hospital, 38 cases of AECOPD combined with pulmonary hypertension patients as a experimental group, 46 cases of simple AECOPD patients in the same period as the controlgroup. And we collected basic data. The serum of Interleukin-6 (IL-6) , Procalcitonin (PCT) , High sensitive C reactive protein (hs-CRP) , N-Terminal pro-Brain natriuretic peptide (NT-proBNP) were collected after admission within 24 hours, the results of Chest CT and Ultrasonic echocardiography. Compared with the control group and experimental group of two groups in the above indicators. Re s ults AECOPD combined with PH group of the smoking index, hs-CRP, PCT, NT-proBNP were higher than the simple AECOPD group (P <0.05) , and had positive correlation with pulmonary artery systolic pressure (P<0.05) . Logistic regression analysis showed that NT-proBNP was an independent risk factor for pulmonary arterial hypertension (OR=1.89, P<0.01) .Clolus ions Smoking and serum hs-CRP, PCT, NT-proB NP are positively correlated with elevated pulmonary artery pressure, NT-proB NP is an independent risk factor for pulmonary arterial hypertension. Smoking and systemic inflammation are involved in the formation of pulmonary hypertension in COPD.
- Acute exacerbation of chronic obstructive pulmonary disease,
- Pulmonary arterial hypertension,
- Smoking,
- Pulmonary arterial hypertension

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References(23)

References

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