Analysis of Differential Expression Genes and Signal Pathways Associated with Cisplatin Resistant Ovarian Cancer

Hu Wan Qin; Zhao Hong Bo; Liang Hong; Zhao Qing Hua; Yang Li Hua

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Hu Wan Qin , Zhao Hong Bo , Liang Hong , Zhao Qing Hua , Yang Li Hua . Analysis of Differential Expression Genes and Signal Pathways Associated with Cisplatin Resistant Ovarian Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 97-101.

Citation:

Hu Wan Qin , Zhao Hong Bo , Liang Hong , Zhao Qing Hua , Yang Li Hua . Analysis of Differential Expression Genes and Signal Pathways Associated with Cisplatin Resistant Ovarian Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 97-101.

Citation:

Hu Wan Qin , Zhao Hong Bo , Liang Hong , Zhao Qing Hua , Yang Li Hua . Analysis of Differential Expression Genes and Signal Pathways Associated with Cisplatin Resistant Ovarian Cancer[J]. Journal of Kunming Medical University, 2017, 38(06): 97-101.

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Analysis of Differential Expression Genes and Signal Pathways Associated with Cisplatin Resistant Ovarian Cancer

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基金：云南省卫生和计划生育委员会医学学科带头人培养项目 (D-201633); 国家自然科学基金资助项目 (81360336);

Received Date: 2017-04-13

Abstract

Abstract

Objective To analyze the differentially expressed genes and signaling pathways in cisplatin resistant ovarian cancer. Me thods Cisplatin resistant ovarian cancer gene set GSE15372 was obtained from the GEO database of the national information center of the United States. The Differential expression gene analysis was performed by R and Bioconductor software, the GO and KEGG pathway of the differentially expressed genes were analyzed by DAVID online tool. Results 211 differentially expressed genes were obtained, including 120 up-and91 down-regulated genes as the standa rd was set that fold change was more than 2 times and FDR was less than0.05. Gene enrichment analysis of differentially expressed genes found in focal adhesion, TGF-beta signaling pathways and other biological processes (P<0.05) . Conclus ion There are some specific differentially expressed genes in the cisplatin resistant ovarian cancer, partial signal pathways were obvious enrichment in the cisplatin resistant ovarian cancer.
- Gene expression profile,
- Cisplatin resistant ovarian cancer,
- Differentially expressed genes,
- Enrichment analysis

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References(15)

References

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