Expression of Survivin in Circulating Tumor Cells in Patients with Bladder Cancer

Yan Yong; Sun Xuan; Li Gang; Zheng Cuan; Ma Shao Xiang; Li Yong; Zhao Run Heng; Wang Ke

Volume 38 Issue 07

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Yan Yong , Sun Xuan , Li Gang , Zheng Cuan , Ma Shao Xiang , Li Yong , Zhao Run Heng , Wang Ke . Expression of Survivin in Circulating Tumor Cells in Patients with Bladder Cancer[J]. Journal of Kunming Medical University, 2017, 38(07): 102-106.

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Expression of Survivin in Circulating Tumor Cells in Patients with Bladder Cancer

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基金：昆明市科技局科研基金资助项目 (2015-2-S-01577);

Received Date: 2017-04-19

Abstract

Abstract

Objective To investigate the expression of Survivin in circulating tumor cells (CTC) and the association between CTC and clinicopathologic characteristics of bladder cancer. Methods Clinically confirmed 50 bladder cancer patients were enrolled in the study. Can Patrol technology was applied to determine different types of CTC. And expressions of Survivin in these CTC were detected by immunohistochemical procedures. C2 test and multi-variates Logistic regression were employed to determine the association between Survivin in CTC and clinicopathologic characteristics of tumors. Results The positive rate of CTC in bladder cancer was 42% (21/50) .The mesenchymal type CTC had the most expression of Survivin (90.9%, with P<0.05) . The presence of CTC and positive expression of Survivin were correlated with tumor size, number of tumor, pathological stage, and pathological grade (P<0.05) . Multivariate analysis confirmed that the presences of CTC and positive expression of Survivin were significant correlated with tumor size, pathological stage, and pathological grade (P <0.05) .Conclusion The presence of CTC and expression of Survivin may suggest the re-occurrence, progression and metastasis of bladder tumor.
- Bladder neoplasms,
- Circulating tumor cells,
- Survivin

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References

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