Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma by Recombinant Human Vascular Endostatin Combined with Chemoradiotherapy

Shang Yi Tai; Yang Jie; Li Lei; Li Xiao Jiang

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Shang Yi Tai , Yang Jie , Li Lei , Li Xiao Jiang . Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma by Recombinant Human Vascular Endostatin Combined with Chemoradiotherapy[J]. Journal of Kunming Medical University, 2017, 38(07): 80-84.

Citation:

Shang Yi Tai , Yang Jie , Li Lei , Li Xiao Jiang . Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma by Recombinant Human Vascular Endostatin Combined with Chemoradiotherapy[J]. Journal of Kunming Medical University, 2017, 38(07): 80-84.

Citation:

Shang Yi Tai , Yang Jie , Li Lei , Li Xiao Jiang . Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma by Recombinant Human Vascular Endostatin Combined with Chemoradiotherapy[J]. Journal of Kunming Medical University, 2017, 38(07): 80-84.

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Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma by Recombinant Human Vascular Endostatin Combined with Chemoradiotherapy

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FZ037);

Received Date: 2017-03-14

Abstract

Abstract

Objective To analyze the therapeutic efficacy of chemoradiotherapy combined with recombinant human vascular endostatin (endostar) in the treatment of locally advanced head and neck squamous cell carcinoma.Methods From July 2011 to June 2014, data of the patients with locally advanced head and neck squamous cell carcinomas were collected, including 46 patients with chemoradiotherapy combined with endostar and 45 patients with chemoradiotherapy only and the two groups were divided: endostar groups (46 patients) and control group (45 patients) . Objective response rates, disease control rate, overall survival (OS) , and progress free survival (PFS) were compared. Quality of Life Questionnaire from University of Washington was applied to evaluate the life quality of the two groups. Results The objective response rate of endostar group and control group were 87.0% and 75.6% respectively (χ2=1.946, P>0.05) , disease control rate being 97.8% and 95.6% respectively (χ2=0.368, P>0.05) , the median PFS being 18.7 months and 14.7 months respectively (P<0.05) , and median OS being 26.8 months and 23.6 months respectively (P>0.05) . The adverse reaction rate were similar between the two groups. The scores of quality of life, including mood and anxiety domain and total score, in endostar group were higher than those in control group (P <0.05) . Conclusion Endostar combined with chemoradiotherapy can enhance the therapeutic effect of locally advanced head and neck squamous cell carcinoma, prolong free survival progress, improve the quality of life and does not increase adverse reaction rate. But the survival benefit for patients still needs further study.
- Head and Neck Neoplasms,
- Angiogenesis Inhibitors,
- Endostatin

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References(12)

References

[1]	[1]FERLAY J, SHIN H R, BRAY F, et al.Estimates of worldwide burden of cancer in 2008:GLOBOCAN 2008[J].Int J Cancer, 2010, 127 (12) :2893-2917.
[2]	[2]SEIWERT T Y, SALAMA J K, VOKES E E.The chemoradiation paradigm in head and neck cancer[J].Nat Clin Pract Oncol, 2007, 4 (3) :156-171.
[3]曹素杰, 张育红.头颈部鳞癌切除患者近期生活质量的影响因素[J].现代肿瘤医学, 2016, 24 (2) :219-221.
[4]	[4]FOLKMAN J.Tumor angiogenesis:Therapeutrc implication[J].N End J Med, 1971, 285 (21) :1182-1187.
[5]	[5]NEUCHRIST C, EROVIC B M, HANDISURYA A, et al.Vascular endothelial growth factor receptor 2 (VEGFR2) expression in squamous cell carcinomas of the head and neck[J].Laryngoscope, 2001, 111 (10) :1834-1841.
[6]	[6]NEUCHRIST C, EROVIC BM, HANDISURYA A, et al.Vascular endothelial growth factor C and vascular endothelial growth factor receptor 3 expression in squamous cell carcinomas of the head and neck[J].Head Neck, 2003, 25 (6) :464-474.
[7]	[7]RIEDEL F, GOTTE K, LI M, et al.Abrogation of VEGF expression in human head and neck squamous cell carcinoma decreases angiogenic activity in vitro and in vivo[J].Int J Oncol, 2003, 23 (3) :577-583.
[8]	[8] KIM Y M, HWANG S, KIM Y M, et al.Endostatin blocks vascular endothelial growth factor-mediated signaling via direct interaction with KDR/Flk-1[J].JBC, 2002, 277 (31) :27872-27879.
[9]	[9]WEN Y E, RANYI LIU, CHANGCHUAN PAN, et al.multicenter randomized phase 2 clinical trial of a recombinant human endostatin adenovirus in patients with advanced head and neck carcinoma[J].Mol Ther, 2014, 22 (6) :1221-1229.
[10]	[10]FURY M G, LEE N Y, SHERMAN E, et al.A phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer[J].Cancer, 2012, 118 (20) :5008-5014.
[11]	[11]MA X, YAO Y, YUAN D, et al.Recombinant human endostatinendostar suppresses angiogenesis and lymphangiogenesis of malignant pleural effusion in mice[J].PLo S One, 2012, 7 (12) :e53449.
[12]牛牛, 李宝兰, 刘朝阳, 等.重组人血管内皮抑制素联合贝伐珠单抗体内抑瘤作用的效果及分析[J].中国肺癌杂志, 2013, 16 (02) :61-66.

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