Expression of Glucose-regulated Protein 94 in Cervical Lesion

Liu Hui Jin; Yang Ying Ying; Pan Jing; Liu Yang; Li Xiao Yi; Zhou Hong Lin

Volume 38 Issue 07

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Liu Hui Jin , Yang Ying Ying , Pan Jing , Liu Yang , Li Xiao Yi , Zhou Hong Lin . Expression of Glucose-regulated Protein 94 in Cervical Lesion[J]. Journal of Kunming Medical University, 2017, 38(07): 99-101.

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Expression of Glucose-regulated Protein 94 in Cervical Lesion

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基金：云南省宫颈阴道疾病中心项目 (2014NS091);

Received Date: 2017-03-02

Abstract

Abstract

Objective To explore the expression and significance of glucose-regulated protein 94 in cervical lesions and HPV infection. Methods Patients from the department of gynecology of the second affiliated hospital of Kunming Medical University form October 2014 to June 2016 were chosen to accept cervical cancer screening (HPV and TCT) , and if any result was abnormal, biopsy under colposcope was performed and the cervical tissue was collected. Finally 40 cases with normal cervical tissues, 30 cases with CINI tissues and 30 cases with CINII-III tissues were selected according to pathological findings, with the age range from 25 to 55 years old. The patients who had ever done cervical lesions treatment or was pregnant were not included in the study. Western Blot method was applied to detect the expression of GRP94 protein in normal cervical tissues, CINI and CINII-III. Results The negative and positive expression of GRP94 accounted for 65.0 % and 35.0 % respectively in normal cervical tissues, 40. 0% and 60. 0% respectively in CINI tissues, and 26.6 % and 73.3 % respectively in CINII-III tissues. There was significant difference among the overall positive rates of the three groups. Pairwise comparison showed positive rate of CINII-III group was significantly higher than that of the normal group and no significant difference was found between the positive rate of the CINI group and that of the normal group and that of CINII-III group. Conclusion GRP 94 shows high expression in cervical intraepithelial neoplasias, on the contrary shows lower expression in normal cervical tissue. GRP94 is closely related to the occurrence of cervical lesion.
- Cervical lesions,
- Endoplasmic reticulum,
- Glucose-regulated protein 94,
- Human papillomavirus

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