Effects of Corilagin on Expression of CRP in OX-LDL Injured Macrophage Cells

Zhang Xiao Chao; Shen Zhi Qiang; Yang Ren Hua; Tang Chuan Jing; Bai Lin Ying; He Bo; Chen Peng; Yao Rong Cheng

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Zhang Xiao Chao , Shen Zhi Qiang , Yang Ren Hua , Tang Chuan Jing , Bai Lin Ying , He Bo , Chen Peng , Yao Rong Cheng . Effects of Corilagin on Expression of CRP in OX-LDL Injured Macrophage Cells[J]. Journal of Kunming Medical University, 2017, 38(08): 1-5.

Citation:

Zhang Xiao Chao , Shen Zhi Qiang , Yang Ren Hua , Tang Chuan Jing , Bai Lin Ying , He Bo , Chen Peng , Yao Rong Cheng . Effects of Corilagin on Expression of CRP in OX-LDL Injured Macrophage Cells[J]. Journal of Kunming Medical University, 2017, 38(08): 1-5.

Citation:

Zhang Xiao Chao , Shen Zhi Qiang , Yang Ren Hua , Tang Chuan Jing , Bai Lin Ying , He Bo , Chen Peng , Yao Rong Cheng . Effects of Corilagin on Expression of CRP in OX-LDL Injured Macrophage Cells[J]. Journal of Kunming Medical University, 2017, 38(08): 1-5.

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Effects of Corilagin on Expression of CRP in OX-LDL Injured Macrophage Cells

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基金：国家自然科学基金资助项目 (81260493, 81160401, 81660613); 云南省社会发展计划重点基金资助项目 (2015FA021, 2012FA002); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB103, 2012FB024); 云南省教育厅科学研究基金资助项目 (2015Y154);

Received Date: 2017-05-10

Abstract

Abstract

Objective To investigate the effects of Corilagin on expression of C-reactive protein (CRP) in oxidized low density lipoprotein ( OX-LDL) injured macrophage cells. Methods In vitro, mice monocyte-derived macrophages were prepared to duplicate the injury model caused by OX-LDL; Western blotting essay was used to determine the effect of Corilagin on CRP protein expression and Real time PCR assay was used to study the CRP m RNA expression, respectively. Results Compared with normal control group, the CRP/β-actin and 2-ΔΔCtvalues of OX-LDL injured model group were markedly increased (P<0.05) ;compared with the model group, Corilagin at 3.125-50 μmol/L obviously decreased the values of CRP/β-actin and 2-ΔΔCt (P<0.05) . Conclusion Corilagin could significantly down-regulate protein and m RNA expression of CRP in OX-LDL injured macrophage cells.
- Corilagin,
- Atherosclerosis,
- Macrophage cells,
- C-reactive protein

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References(17)

References

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