Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients

Li Feng

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Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

Citation:

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

Citation:

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

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Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients

Li Feng

Funds:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

Received Date: 2017-04-19

Abstract

Abstract

Objective To investigate the effects of TSGF and HGF in CSF on ECM remodeling in glioma patients. Methods 83 cases of neurosurgery glioblastoma patients including grade Ⅰ 28 cases, 25 cases of patients with grade Ⅱ, Ⅲ grade 20 cases, Ⅳ grade 10 patients were enrolled. TSGF and EGF, MMP-2, TIMP-2, MMP-2/TIMP-2 were detected. Results TSGF and EGF in patients with grade Ⅱ compared with Ⅰappeared significantly higher level (P<0.05) , TSGF and EGF of Ⅲ grade patients compared with grade Ⅰ, Ⅱ grade were significantly higher (P<0.05) , TSGF and EGF of Ⅳ grade compared with gradeⅠ, Ⅱgrade, grade Ⅲ were significantly (P <0.05) . MMP-2, TIMP-2, MMP-2/TIMP-2 in grade Ⅱ patients was significantly different than that in grade Ⅰ (P <0.05) , MMP-2, TIMP-2, MMP-2/TIMP-2 in stage Ⅲpatients compared with Ⅰ, Ⅱ significantly different (P <0.05) , MMP-2, MMP-2/TIMP-2 in stage Ⅳcompared with grade Ⅰ, Ⅱ grade, grade Ⅲ showed significant difference (P <0.05) , TIMP-2 compared with grade Ⅰ, Ⅱ grade showed significant difference (P <0.05) . TSGF with MMP-2, MMP-2/TIMP-2showed significant positive correlation while showed negative correlation with TIMP-2 (P <0.05) , EGF and MMP-2, MMP-2/TIMP-2 showed significant positive correlation while showed negative correlation with TIMP-2 (P<0.05) . Conclusion Elevated cerebrospinal fluid levels of HGF and TSGF are an important factors leading to gliomas progress, the process of ECM remodeling-related factors are closely related to the progress, close monitoring those factors could help to make clear tumor progress.
- Glioma,
- TSGF,
- HGF,
- Remodeling

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References(19)

References

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