Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients

Li Feng

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(08): 102-105

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

Citation:

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

Citation:

Li Feng . Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 102-105.

PDF( 188 KB)

Effects of TSGF and HGF in CSF on ECM Remodeling in Glioma Patients

Li Feng

Funds:

基金：陕西省科技攻关基金资助项目 (2016SF-110);

Received Date: 2017-04-19

Abstract

Abstract

Objective To investigate the effects of TSGF and HGF in CSF on ECM remodeling in glioma patients. Methods 83 cases of neurosurgery glioblastoma patients including grade Ⅰ 28 cases, 25 cases of patients with grade Ⅱ, Ⅲ grade 20 cases, Ⅳ grade 10 patients were enrolled. TSGF and EGF, MMP-2, TIMP-2, MMP-2/TIMP-2 were detected. Results TSGF and EGF in patients with grade Ⅱ compared with Ⅰappeared significantly higher level (P<0.05) , TSGF and EGF of Ⅲ grade patients compared with grade Ⅰ, Ⅱ grade were significantly higher (P<0.05) , TSGF and EGF of Ⅳ grade compared with gradeⅠ, Ⅱgrade, grade Ⅲ were significantly (P <0.05) . MMP-2, TIMP-2, MMP-2/TIMP-2 in grade Ⅱ patients was significantly different than that in grade Ⅰ (P <0.05) , MMP-2, TIMP-2, MMP-2/TIMP-2 in stage Ⅲpatients compared with Ⅰ, Ⅱ significantly different (P <0.05) , MMP-2, MMP-2/TIMP-2 in stage Ⅳcompared with grade Ⅰ, Ⅱ grade, grade Ⅲ showed significant difference (P <0.05) , TIMP-2 compared with grade Ⅰ, Ⅱ grade showed significant difference (P <0.05) . TSGF with MMP-2, MMP-2/TIMP-2showed significant positive correlation while showed negative correlation with TIMP-2 (P <0.05) , EGF and MMP-2, MMP-2/TIMP-2 showed significant positive correlation while showed negative correlation with TIMP-2 (P<0.05) . Conclusion Elevated cerebrospinal fluid levels of HGF and TSGF are an important factors leading to gliomas progress, the process of ECM remodeling-related factors are closely related to the progress, close monitoring those factors could help to make clear tumor progress.
- Glioma,
- TSGF,
- HGF,
- Remodeling

FullText(HTML)

References(19)

References

[1]樊丹丹.PDGF及NSE变化对脑出血患者预后的判断意义[J].国外医学 (医学地理分册) , 2014, 35 (2) :161-163.
[2]	[2]LWIN Z, BROOM A, COSMAN R, et al.Culturally and linguistically diverse patient participation in glioma research[J].Neurooncol Pract, 2014, 1 (3) :101-105.
[3]	[3]SECHLER M, BOROWICZ S, VAN SCOYK M, et al.Novel role for gamma-catenin in the regulation of cancer cell migration via the induction of hepatocyte growth factor activator inhibitor Type 1 (HAI-1) [J].J Biol Chem, 2015, 290 (25) :15610-15620.
[4]	[4]HU Y, WANG J L, TAO H T, et al.Expression and significance of TSGF, CEA and AFP in patients before and after radical surgery for colon cancer[J].Asian Pac J Cancer Prev, 2013, 14 (6) :3877-3880.
[5]李相伍.镁在神经系统疾病中的应用[J].国外医学 (医学地理分册) , 2011, 32 (4) :301-302.
[6]	[6]HUANG H, CHEN A Y, ROJANASAKUL Y, et al.Dietary compounds galangin and myricetin suppress ovarian cancer cell angiogenesis[J].J Funct Foods, 2015, 15 (6) :464-475.
[7]	[7]CHEN Y, GAO S G, CHEN J M, et al.Serum CA242, CA199, CA125, CEA, and TSGF are Biomarkers for the efficacy and prognosis of cryoablation in pancreatic cancer patients[J].Cell Biochem Biophys, 2014, 23 (12) :110-119.
[8]	[8]MAKUSZEWSKA M, SOKOLOWSKA M, HASSMANN-POZNANSKA E, et al.Enhanced expression of hepatocyte growth factor in the healing of experimental acute tympanic membrane perforation[J].Int J Pediatr Otorhinolaryngol, 2015, 79 (7) :987-992.
[9]	[9]WEI P, ZHANG W, YANG L S, et al.Serum GFAP autoantibody as an ELISA-detectable glioma marker[J].Tumour Biol, 2013, 34 (4) :2283-2292.
[10]	[10]KANG M, PEERY A F, LOCKLEAR C, et al.Plasma insulin, glucose, IGF-I, IGF-II, and IGFBP-3 and risk of recurrent colorectal adenomas[J].J Gastroenterol Hepatol Res, 2013, 2 (4) :531-535.
[11]	[11]DONG Z, XU X, DU L, et al.Leptin-mediated regulation of MT1-MMP localization is KIF1B dependent and enhances gastric cancer cell invasion[J].Carcinogenesis, 2015, 34 (5) :974-983.
[12]	[12]WEHR E, PILZ S, BOEHM B O, et al.Low free testoste-rone is associated with heart failure mortality in older men referred for coronary angiography[J].European Journal of Heart Failure, 2015, 13 (5) :482-488.
[13]魏亚辉, 侯保秋.IGF-2及IGFBP-2与脑神经胶质瘤侵袭能力的相关性分析[J].昆明医科大学学报, 2015, 36 (5) :92-95.
[14]	[14]WANG Z, WANG Z, LIANG Z, et al.Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7in serum and lung cancer tissues from patients with nonsmall cell lung cancer[J].Onco Targets Ther, 2013, 16 (6) :1437-1444.
[15]	[15]RU L, ABUDOUHAER A, GUO Y F.Clinical significance of serum levels of IGF-1 and IGFBP-3 in children with henoch-schonlein purpura or henoch-schonlein purpura nephritis[J].Zhongguo Dang Dai Er Ke Za Zhi, 2013, 15 (11) :1009-1013.
[16]	[16]SHRESTHA A, CARNELIO S.Evaluation of matrix metalloproteinases-2 (MMP-2) and tissue inhibitors of metalloproteinases-2 (TIMP-2) in oral submucous fibrosis and their correlation with disease severity[J].Kathmandu Univ Med J (KUMJ) , 2013, 11 (44) :274-281.
[17]	[17]TAS F, KARABULUT S, SERILMEZ M, et al.Clinical significance of serum insulin-like growth factor-1 (IGF-1) and insulinlike growth factor binding protein-3 (IGFBP-3) in patients with epithelial ovarian cancer[J].Tumour Biol, 2014, 35 (4) :3125-3132.
[18]	[18]SRIVASTAVA P, PANDEY S, MITTAL B, et al.No association of matrix metalloproteinase[MMP]-2 (-735C>T) and tissue inhibitor of metalloproteinase[TIMP]-2 (-418G>C) gene polymorphisms with cervical cancer susceptibility[J].Indian J Clin Biochem, 2013, 28 (1) :13-18.
[19]	[19]TURKOGLU O, BECERIK S, TERVAHARTIALA T, et al.The effect of adjunctive chlorhexidine mouthrinse on GCF MMP-8 and TIMP-1 levels in gingivitis:a randomized placebo-controlled study[J].BMC Oral Health, 2014, 14 (1) :55-61.

Relative Articles(20)

Relative Articles

[1]	Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI. Clinical Effect of Reoperation for Recurrent Glioma. Journal of Kunming Medical University, 2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920
[2]	Wenhua XIA, Xiang SUN, Jianlin SHAO. Feasibility of Optic Nerve Sheath Diameter to Guide the Treatment of Dehydration in Patients Undergoing Glioma Surgery. Journal of Kunming Medical University, 2022, 43(6): 117-121. doi: 10.12259/j.issn.2095-610X.S20220620
[3]	Feng Yi , Cai Bing , Wang Feng , Wang Mao De . . Journal of Kunming Medical University, 2020, 41(03): 10-16.
[4]	Wang Hong Yu , Wei Dao , Wang Jin Kun , Yang Zhi Yong , Wang Wei Min , Ding Peng . . Journal of Kunming Medical University, 2020, 41(01): 26-30.
[5]	Chen Xi , Xu Zhi Xing , Liu Xu Jie , Tian Jin Tao , Niu Xiao Qun , Pu Jun . . Journal of Kunming Medical University, 2020, 41(09): 21-25.
[6]	Bai Xiang Feng , Tao Jie , Meng Jun , Yang Wei . Effect of Left Ventricle Reconstruction on Left Ventricular Remolding. Journal of Kunming Medical University, 2017, 38(11): 34-39.
[7]	Wang Jing . In Vitro Anticancer Effect of AMH-T. Journal of Kunming Medical University,
[8]	Yuan Yong . . Journal of Kunming Medical University,
[9]	Wang Can Zhi . . Journal of Kunming Medical University,
[10]	Wei Ya Hui . . Journal of Kunming Medical University,
[11]	Wei Ya Hui . . Journal of Kunming Medical University,
[12]	Hao Jin Gang . . Journal of Kunming Medical University,
[13]	Shi Lei . . Journal of Kunming Medical University,
[14]	Chen Li Xing . . Journal of Kunming Medical University,
[15]	Wu Zhi Ping . . Journal of Kunming Medical University,
[16]	Yang De Biao . . Journal of Kunming Medical University,
[17]	. Study on proNGF Apoptosis Pro-signal in Human Brain Gliomas. Journal of Kunming Medical University,
[18]	. Expression and Clinical Significance of Plasminogen Activator Inhibitor Type-1 in Human Glioma. Journal of Kunming Medical University,
[19]	Su Xing . . Journal of Kunming Medical University,
[20]	. The Expression Significance and Relationship Study of SDF-1 and VEGF in Glioma. Journal of Kunming Medical University,