Effects of Rosemary on Anxiety of Rats with Multiple Concussions

Zhang Rui; Zheng Yong Jiang; Cai Bin; Wang Zhen; Li Yu Hua; Cao Zhen Zhen; Zhang Huan; Zhang Rong Ping; Yu Jian Yun

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Zhang Rui , Zheng Yong Jiang , Cai Bin , Wang Zhen , Li Yu Hua , Cao Zhen Zhen , Zhang Huan , Zhang Rong Ping , Yu Jian Yun . Effects of Rosemary on Anxiety of Rats with Multiple Concussions[J]. Journal of Kunming Medical University, 2017, 38(08): 11-15.

Citation:

Zhang Rui , Zheng Yong Jiang , Cai Bin , Wang Zhen , Li Yu Hua , Cao Zhen Zhen , Zhang Huan , Zhang Rong Ping , Yu Jian Yun . Effects of Rosemary on Anxiety of Rats with Multiple Concussions[J]. Journal of Kunming Medical University, 2017, 38(08): 11-15.

Citation:

Zhang Rui , Zheng Yong Jiang , Cai Bin , Wang Zhen , Li Yu Hua , Cao Zhen Zhen , Zhang Huan , Zhang Rong Ping , Yu Jian Yun . Effects of Rosemary on Anxiety of Rats with Multiple Concussions[J]. Journal of Kunming Medical University, 2017, 38(08): 11-15.

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Effects of Rosemary on Anxiety of Rats with Multiple Concussions

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基金：国家自然科学基金资助项目 (81360467); 云南省自然科学基金资助项目 (2013FB104);

Received Date: 2017-05-03

Abstract

Abstract

Objective To investigate the possible effects of rosemary on anxiety in rats with multiple concussions. Methods The rat model of three-fold cerebral concussion (3MCC) was performed using a metallic pendulum striker concussive device. Then the rats were randomly divided into six groups:high dose of rosemary intervention group (H) , medium dose of rosemary intervention group (M) , low doses of rosemary intervention group (L) , tween control group (T) , Normal control group (N) , 3MCC injury group (I) . The effect of regular rosemary infusion on anxiety was assessed by open field test. Results (1) Compared with N group: rats of the rest of the groups spent less time in the central area and more time in the surrounding area. The number of total grid, and central grid, however, the number of surrounding grid were less in all groups except M group. (2) Compared with I group:Rats in rosemary intervention groups spent more time in central area and less time in surrounding ares. And the number of total grid in rosemary intervention groups were more. The number of central grid and surrounding grid were obviously more than I group. Moreover, rearing time among all groups have no significant changes. Conclusion The rats can develop anxiety on the 17 th day after three-fold cerebral concussion, and rosemary has a significant anti-anxiety affect on multiple concussions.
- Rosemary,
- Multiply cerebral concussion,
- Open field test,
- Anxiety,
- Rats

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References(20)

References

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