趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布

Chen Zhi Bin; Mo Yan Ping; Yang Yu; Chen Can Kun; Yang Jing Yi; Wan Rui Xue; Fan Zhi Xiang; Long Li

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Chen Zhi Bin , Mo Yan Ping , Yang Yu , Chen Can Kun , Yang Jing Yi , Wan Rui Xue , Fan Zhi Xiang , Long Li . 趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布[J]. Journal of Kunming Medical University, 2017, 38(08): 35-39.

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Chen Zhi Bin , Mo Yan Ping , Yang Yu , Chen Can Kun , Yang Jing Yi , Wan Rui Xue , Fan Zhi Xiang , Long Li . 趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布[J]. Journal of Kunming Medical University, 2017, 38(08): 35-39.

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趋化因子受体CX3CR1基因T280M多态性在云南彝族人群中的分布

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基金：国家自然科学基金资助项目 (81160164); 云南省自然科学基金资助项目 (2008CD117); 昆明医科大学大学生创新性实验计划基金资助项目 (昆医大〔2017〕2号);

Received Date: 2017-05-13

Abstract

Abstract

目的研究云南省晋宁县彝族人群CX3CR1基因T280M多态性分布的情况, 为探讨CX3CR1基因相关性疾病的发病机制奠定基础.方法采用PCR-RFLP技术对居住在云南省晋宁县268例彝族健康个体的CX3CR1基因T280M多态性进行分析, 计算MM、MT、TT基因型频率和M、T等位基因频率, 与其他人群该位点多态性进行比较.结果云南省晋宁县彝族CX3CR1基因的MM、MT、TT基因型频率分别为1.12%、11.94%和86.94%, M和T等位基因频率分别为7.09%和92.91%.与汉族、维吾尔族、希腊、法国、塞尔维亚、印度、意大利和高加索人群比较, 无论是基因型分布还是基因频率差异有统计学意义 (P<0.05) p="">0.05) .结论 CX3CR1基因T280M多态性分布存在民族、种族差异, 且种族间的差异大于民族间的差异.
- CX3CR1 gene,
- Genetic polymorphism,
- Yi nationality,
- Distribution

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References(27)

References

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