Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines

Zhang Jin Pei; Yang Yi; Jin Yan

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Zhang Jin Pei , Yang Yi , Jin Yan . Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines[J]. Journal of Kunming Medical University, 2017, 38(08): 40-43.

Citation:

Zhang Jin Pei , Yang Yi , Jin Yan . Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines[J]. Journal of Kunming Medical University, 2017, 38(08): 40-43.

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Effect of Ma Xiong Shu Tong Fang on Migraine and Its Influence on Serum Levels of 5-HT, NF-NF-κB and Inflamatory Cytokines

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基金：国家自然科学基金资助项目 (81470188);

Received Date: 2017-05-10

Abstract

Abstract

Objective To study the safety and effectiveness of Ma Xiong Shu Tong Fang for migraine and evaluate the white matter lesions (WML) by brain MRI.Methods A total of 122 consecutives were randomly divided into control and observation groups and each group had 61 cases.The patients in control group received Flunarizine Hydrochloride Capsules 10 mg/d, and the patients in observation group adopted Ma Xiong Shu Tong Fang three particles per day, and the course was four weeks. Then we compared TCM syndrome integrals, total effective rate and incidence of adverse reactions, serum 5-HT, NF-κB, IL-6 and TNF-αlevels, positive rate and degrees of WML by MRI. Results The TCM syndrome integrals after treatment in observation group was significantly lower than control group (P <0.05) . There were no severe complications in the two groups. The serum 5-HT, NF-κB, IL-6 and TNF-αlevels in observation group were all lower, positive rate of WML was also lower (P<0.05) . Conclusion Ma Xiong Shu Tong Fang is safe and effective for mgraine, it can reduce serum levels of 5-HT, NF-κB, IL-6 and TNF-αand improve WML.
- Ma Xiong Shu Tong Fang,
- Migraine,
- White matter lesions,
- 5-HT,
- NF-κB,
- IL-6

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References(9)

References

[1]谭亮, 樊光辉.偏头痛发病机制的研究进展[J].中国临床神经外科杂志, 2012, 17 (9) :571-573.

[2]郭宇博.不同配伍中药方剂对偏头痛大鼠血清和脑组织中5-HT含量的影响[J].中国中医基础医学杂志, 2010, 16 (3) :206-208.

[3]董正妮, 尹丽丽.活血平肝通络法治疗偏头痛的临床与实验研究进展[J].中西医结合心脑血管病杂志, 2016, 14 (24) :2905-2907.

[4]偏头痛诊断与防治专家共识组.偏头痛诊断与防治专家共识[J].中华内科杂志, 2006, 45 (1) :694.

[5]郭宇洁, 刘建勋.中药方剂 (麻芎舒痛方) 组方设计方法研究[D].北京:中国中医科学院博士学位论文, 2009.

[6]杨胜, 张定堃, 苏柘僮, 等.川芎-白芷药对不同配比不同剂型对偏头痛动物模型的影响[J].中国实验方剂学杂志, 2011, 17 (14) :225-228.

[7]王强, 沈岚, 梁爽, 等.川芎对天麻指标成分在偏头痛大鼠体内药动学的影响[J].中成药, 2015, 37 (1) :62-69.

[8]秦旭华, 李祖伦, 金沈锐.白芷总香豆素对偏头痛模型小鼠5-HT和MAO的影响[J].时珍国医国药, 2012, 23 (9) :2190-2191.

[9]张素慧, 宁炼, 石劲敏, 等.葛根总黄酮经鼻给药对硝酸甘油致偏头痛模型大鼠的保护作用[J].中国新药与临床杂志, 2013, 32 (5) :394-398.

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