Clinical Analysis of Familial Essential Tremor

Hou Li Jun; Zhu Yu Hong; Li Yan; He Yong Jing; Lv Le Chun; Liu Wen Jun; Geng Li Rong

Article Contents

Article Navigation > Journal of Kunming Medical University > 2017 > 38(08): 53-57

Hou Li Jun , Zhu Yu Hong , Li Yan , He Yong Jing , Lv Le Chun , Liu Wen Jun , Geng Li Rong . Clinical Analysis of Familial Essential Tremor[J]. Journal of Kunming Medical University, 2017, 38(08): 53-57.

Citation:

Hou Li Jun , Zhu Yu Hong , Li Yan , He Yong Jing , Lv Le Chun , Liu Wen Jun , Geng Li Rong . Clinical Analysis of Familial Essential Tremor[J]. Journal of Kunming Medical University, 2017, 38(08): 53-57.

Citation:

PDF( 455 KB)

Clinical Analysis of Familial Essential Tremor

Funds:

基金：国家自然科学基金资助项目 (81660319); 云南省科技厅联合专项基金资助项目 (2008CD018);

Received Date: 2017-05-09

Abstract

Abstract

Objective To further understand the genetic characteristics and the outcome of Familial essential tremor.Methods Clinical summary and statistical analysis were performed on the onset age, course of disease of ET, whether it is related to tremor amplitude, drug sensitivity and complication of 39 patients in 7families. Results The correlation coefficient between tremor amplitude and age at onset was rs =0.542, Correlation coefficient of tremor amplitude and duration rs =0.168; The effective rates of oral propranolol in young middle-aged group and elderly group were 79.2% and 35.7%, P=0.014; The effective rates of drinking test were 66.7% and 28.6%, P = 0.042, respectively, in young middle-aged group and elderly group;The incidence of complications in young middle-aged group and elderly group was 8.3% and 42.9%, respectivdy P =0.042.Conclusions With the growth of onset age, hearing loss and cognitive decline and other complications increase significantly; With the duration of the disease, tremor increases amplitude, drug sensitivity gradually decreases.It suggests that ET is easy to transform to other degenerative diseases, also easy to merge other degenerative diseases, This change has a certain relevance with age and heredity. Is is rather than a simple benign disease.
- Familial essential tremor (FET) ,
- Parkinson's disease (PD) ,
- Tremor amplitude orthostatic tremor,
- OT

FullText(HTML)

References(19)

References

[1]蒋雨平, 王坚, 蒋雯巍, 等.新编神经疾病学[M].上海:上海科学普及出版社, 2014:378-379.
[2]中华医学会神经病学分会帕金森病及运动障碍学组.原发性震颤的诊断和治疗指南[J].中华神经科杂志, 2009, 42 (8) :571-572.
[3]	[3]SULICA L, LOUIS E D.Clinical characteristics of essential voice tremor:a study of 34 cases[J].Laryngoscope, 2010, 120 (3) :516.
[4]简斌, 张涛, 肖俊会.云南汉族人群CYP2C19基因多态性分析[J].昆明医科大学学报, 2015, 36 (11) :17-19.
[5]	[5]BENITO-LEON J, LOUIS E D.Update on essential tremor[J].Minerva Med, 2011, 102 (6) :417.
[6]	[6]BUIJINK A W, BROERSMA M.Cerebellar Atrophy in Cortical Myoclonic Tremor and Not in Hereditary Essential Tremor-a Voxel-Based Morphometry Study[J].Cerebellum, 2016, 15 (6) :696-704.
[7]王波, 安鸿飞, 张洁, 等.3.0T MR磁敏感加权成像对早期帕金森病黑质致密带的研究[J].昆明医科大学学报, 2014, 35 (2) :27-30.
[8]赵英, 武绍远, 吴昆华.帕金森氏病精神障碍的磁共振弥散张量[J].研究昆明医科大学学报, 2014, 35 (1) :63-67.
[9]	[9]YILMAZ N H, AKBOSTANCI M C, YILMAZ N.Sensorineural hearing loss in non-depressed essential tremor cases and controls:A clinical and audiometric study[J].Tremor&Other Hyperkinetic Movements, 2015, 29 (5) :281.
[10]	[10]LOUIS E D.Essential Tremor:A common disorder of purkinje neurons[J].Neuroscientist, 2015, 22 (2) :108-118.
[11]	[11]WU Y W, PRAKASHK, RONG T Y, e tal.Lingo2variants associated With essential tremor and Parkinson'sdisease[J].Human Genetics, 2011, 129 (11) :611-615.
[12]和茵, 赵丹楠, 王云燕.脑电深部刺激法治疗帕金森病的护理体会[J].昆明医科大学学报, 2015, 36 (1) :176-177.
[13]耿鑫, 龚会军, 余化霖.脑深部电刺激治疗帕金森病1例报道[J].昆明医科大学学报, 2014, 35 (5) :153-155.
[14]黄微, 陈晶菁, 戴萍.原发性震颤误诊为帕金森病25例临床分析[J].昆明医科大学学报, 2015, 36 (5) :150-152.
[15]	[15]YALTHO T C, ONDO W G.Orthostatic tremor A review of 45 cases[J].Parkinsonism Relat Disord, 2014, 20 (7) :723-725.
[16]何月, 彭巧玲, 周国庆.帕金森病患者血尿酸水平与认知功能的相关性研究[J].川北医学院学报, 2016, 31 (2) :214-216.
[17]张树山, 朱陶, 李程旭, 帕金森病非运动症状临床特点研究[J].川北医学院学报, 2016, 31 (4) :520-524.
[18]鲍娟, 谈跃, 曹海.帕金森病患者轻度认知损害与胰岛素抵抗的相关性[J].昆明医科大学学报, 2015, 36 (12) :47-51.
[19]黄璞, 李国萍, 陈绍春.FUS/TLS在基因表达调控中的作用及与神经退行性疾病的关系[J].昆明医科大学学报, 2016, 37 (8) :1-4.

Relative Articles(20)

Relative Articles

[1]	Mengshu YANG, Xiaoyun KONG, Huan LI, Yanwei ZOU, Yihao WANG, Ci DONG. Clinical Study on the Effect of Cognitive Behavioral Therapy for Insomnia on Patients with Parkinson’s Disease with Insomnia. Journal of Kunming Medical University, 2023, 44(8): 117-122. doi: 10.12259/j.issn.2095-610X.S20230806
[2]	Yunxin ZHAO, Fanyuan MENG, Wei LIU, Huidong WU, Changliang LUO, Bin LI, Lijuan AO, Moxian CHEN. Research Progress of Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis. Journal of Kunming Medical University, 2022, 43(11): 156-164. doi: 10.12259/j.issn.2095-610X.S20221121
[3]	Yi-sheng QIAO, Xiao-xiang CHEN, Jiao-tian XU, Wei WANG, Chao ZHANG, Xiao-bin SONG, Zhi-yong YANG, Xing-li DENG. Transplantation of Nurr1 Gene-modified Embryo Midbrain Neural Stem Cells for Treatment in Parkinson’ s Disease. Journal of Kunming Medical University, 2021, 42(8): 1-6. doi: 10.12259/j.issn.2095-610X.S20210801
[4]	Yi-sheng QIAO, Xiao-xiang CHEN, Jiao-tian XU, Wei WANG, Chao ZHANG, Xiao-bin SONG, Zhi-yong YANG, Xing-li DENG. Transplantation of Nurr1 Gene-modified Embryo Midbrain Neural Stem Cells for Treatment of Parkinson’s Rats. Journal of Kunming Medical University, 2021, 42(): 1-6. doi: 10.12259/j.issn.2095-610X.S20210919
[5]	Hong-mei FANG, Guo-dong SU, Lu-gang WEI, Rui LI, Sha WU, Yi-jian LONG. Clinical Effect of MHI on Diaphragm Motion Amplitude and BI Index in Stroke Patients. Journal of Kunming Medical University, 2021, 42(2): 137-139. doi: 10.12259/j.issn.2095-610X.S20210205
[6]	Bo LI, Jian-lin JIAO, Chuan-yi ZHANG, Ya-qiong QIU, Hao GUO, Huai-chang SUN, Zhi-cheng YU. The Electroencephalogram and Analysis of MPTP-Induced Tree Shrew Model for Parkinson's Disease. Journal of Kunming Medical University, 2021, 42(5): 29-34. doi: 10.12259/j.issn.2095-610X.S20210506
[7]	Zhang Xu Xiang , Li Wen , Wang Fang , Lin Meng Jie , Li Hong , Zhang Li , Nian Xin . . Journal of Kunming Medical University, 2020, 41(05): 18-22.
[8]	Tian Yun Ping , Zou Yan Qiu Shuo , Jin Li , Zhao Jiang , Ren Xiang , Yin Jian Wen . Molecular Typing and Drug Resistance of Salmonella Typhimurium in Yunnan Province. Journal of Kunming Medical University, 2018, 39(08): 23-27.
[9]	Huang Wei , Dai Ping , Yin Yan , Zhang Ling , Jia Fan , Guo Ling , Li Jing Tao . . Journal of Kunming Medical University, 2017, 38(05): 129-132.
[10]	Shi Guo Lin . Analysis of Effectiveness of Deep Brain Stimulation for Forty Cases of Parkinson’s Disease. Journal of Kunming Medical University,
[11]	Nian Xin . Difference of Metallothionein Gene G-201A Polymorphism in Type 2 Diabetes and Essential Hypertension. Journal of Kunming Medical University,
[12]	Bao Juan . . Journal of Kunming Medical University,
[13]	He Yin . . Journal of Kunming Medical University,
[14]	Huang Wei . . Journal of Kunming Medical University,
[15]	Wang Bo . . Journal of Kunming Medical University,
[16]	Geng Xin . . Journal of Kunming Medical University,
[17]	Zhao Ying . . Journal of Kunming Medical University,
[18]	Tang Li Li . . Journal of Kunming Medical University,
[19]	Lu Ping . . Journal of Kunming Medical University,
[20]	. . Journal of Kunming Medical University,