The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP

Huang Ying; Liu Yi Han; Li Cheng Ping; Wu Kun; Zeng Yun

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Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2017, 38(08): 67-72.

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Huang Ying , Liu Yi Han , Li Cheng Ping , Wu Kun , Zeng Yun . The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP[J]. Journal of Kunming Medical University, 2017, 38(08): 67-72.

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The Expression and Significance of IL-17 and IL-23 in Patients with B-cell non-Hodgkin Lymphoma Treated by RCHOP

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基金：云南省教育厅科学研究基金资助项目 (2013Y292);

Received Date: 2017-05-03

Abstract

Abstract

Objectives To detect the expression levels of IL-17 and IL-23 in peripheral blood of B-cell non-Hodgkin lymphoma patients treated by RCHOP and to study the role of IL-17 and IL-23 in NHL.Methods Twenty-five patients with B-cell NHL who achieved remission after 6 to 8 cycles of R-CHOP as a NHL group, 20 healthy volunteers were recruited as a normal control group.RT-PCR was used to detect the expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients and health volunteers.Results The expression levels of IL-17 m RNA and IL-23 m RNA in the patients with NHL before therapy and the patients with NHL who achieved remission were lower than that in the normal control group (P<0.05) .The expression levels of IL-17 m RNA and IL-23 m RNA in the patients with NHL who achieved remission were higher than that in the patients with NHL before therapy (P=0.001, P<0.05) .Conclusions IL-17 and IL-23 m RNA levels are higher after treated with R-CHOP. The expression levels of IL-17 m RNA and IL-23 m RNA in NHL patients are related with prognosis and efficacy.
- Non-Hodgkin lymphoma,
- Interleukin-17,
- Interleukin-23,
- Rituximab,
- Prognosis

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References(13)

References

[1]	[1]SIEGEL R L, MILLER K D, JEMAL A.Cancer statistics, 2015[J].CA Cancer J Clin, 2015, 65 (1) :5-29.
[2]	[2]STASICR, DELPOETAG, STIPAE, et al.Response to B-cell depleting therapy with rituximab reverts the abnormalities of T-cell subsets in patients with idiopathic thrombocytopenic purpura[J].Blood, 2007, 110 (8) :2924-2930.
[3]	[3]STASI R, COOPERN, DELPOETAG, et al.Analysis of regulatory T-cell changes in patients with idiopathic thrombocytopenic purpura receiving B cell-depleting therapy with rituximab[J].Blood, 2008, 112 (4) :1147-1150.
[4]	[4]SHAHRARAS, HUANGQ, MANDELINAM, et al.TH-17 cells in rheumatoid arthritis[J].Arthritis Res Ther, 2008, 10 (4) :R93.
[5]	[5]RACKEMK.Immunopathogenesis of multiple sclerosis[J].Ann Indian Acad Neurol, 2009, 12 (4) :215-220.
[6]	[6]ZHOU L, LITTMANDR.Transcriptional regulatory networks in Th17 cell differentiation[J].Curr Opin Immunol, 2009, 21 (2) :146-152.
[7]	[7]STARK M A, HUO Y, BURCIN T L, et al.Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17[J].Immunity, 2005, 22 (3) :285-294.
[8]	[8]TZANKOVA, MEIERC, HIRSCHMANNP, et al.Correlation of high numbers of intratumoral FOXP3+regulatory T cells with improved survival in germinal center like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma[J].Haematologica, 2008, 93 (2) :193-200.
[9]	[9]GHILARDIN, OUYANGW.Targeting the development and effector functions of TH17 cells[J].Semin Immunol, 2007, 19 (6) :383-393.
[10]	[10]SAKAGUCHI S.Regulatory T cells:Key controllers of immunologic self-tolerance[J].Cell, 2000, 101 (5) :455-458.
[11]	[11]PARK H, LIZ, YANGXO, et al.A distinct lineage of CD4T cells regulates tissue inflammation by producing interleukin 17[J].Nat Immunol, 2005, 6 (11) :1133-1141.
[12]	[12]OPPMANNB, LESLEYR, BLOMB, et al.Novel p19 protein engages IL-12p40 to form a cytokine from a cytokine, IL-23, with biological activities similar as well as distinct from IL-12[J].Immunity, 2000, 13 (5) :715-725.
[13]	[13]LU T, YUS, LIUY, et al.Aberrant circulating Th17 cells in patients with B-cell non-hodgkin’s lymphoma[J].PLo S One, 2016, 11 (1) :e0148044.

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