Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients

Xiang Xi; Li Wan Bi; Zhang Xian; Liu Hua; Wang Yu Ming; Yang Cai; Bai Yun Xia

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Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 79-85.

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Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 79-85.

Citation:

Xiang Xi , Li Wan Bi , Zhang Xian , Liu Hua , Wang Yu Ming , Yang Cai , Bai Yun Xia . Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients[J]. Journal of Kunming Medical University, 2017, 38(08): 79-85.

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Correlation between Vitamin D Receptor (VDR) Gene ApaⅠ, BsmⅠ Single Nucleotide Polymorphism and Diabetic Kidney Disease in Type 2 Diabetic Patients

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2012FB085); 云南省教育厅科学研究基金资助项目 (2012C020);

Received Date: 2017-05-22

Abstract

Abstract

Objetive To investgate the association of Vitamin D receptor gene ApaⅠ, BsmⅠ single nucleotide polymorphism with diabetic kidney disease in type 2 diabetic patients.Methods The single nucleotide polymorphism of VDR gene in 235 type 2 diabetes [including 82 normal albuminuria (DKD0 group) , 66microalbuminuria (DKDl group) and 87 macroalbuminuria (DKD2 group) ]and 86 normal controls were detected by Taq Man fluorescent probe. The genotype frequency and allele frequency and relative clinical datawere compared among groups. Results (1) BsmⅠ GG, GA, AA genotype frequencies were 0.931, 0.066, 0.003, allele G and allele G frequencies were 0.964 and 0.036. ApaⅠ CC、CA、AA genotype frequencies were0.536, 0.371, 0.093, allele C and allele A frequencies were 0.721 and 0.279. (2) ApaⅠ allele C frequencies (P<0.05) in DKD2 group (0.770) were significantly higher than in DKD0 group (0.671) , and the allele A frequencies (P<0.05) in DKD2 group (0.230) were significantly lower than in DKD0 group (0.329) (P<0.05) . (3) Logistic analysis showed that BsmⅠ GG genotype (OR = 0.159, P<0.05) was the independent protective factors of DKD occurrence, but it was not related to T2 DKD development. ApaⅠ single nucleotide polymorphism was not related to T2 DKD occurrence and development ( P >0.05) . 25 ( OH) D deficiency/insufficiency may b e the independent risk factor of T2 DKD development (OR = 1.957, P <0.05) .Conclusions BsmⅠ GG genotype is an independent protective factor of T2 DKDoccurrence, but it is not related to T2 DKD development.ApaⅠ singlenucleotide polymorphism is not related to T2 DKD occurrence and development.
- Vitamin D receptor gene,
- Single nucleotide polymorphism,
- Type 2 diabetes mellitus,
- Diabetic kidney disease,
- 25-hydroxy-vitamin D

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References(32)

References

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