Effects of Different Feeding Space on Estradiol and Bone Metabolism Index in Tree Shrews with Osteoporosis

Li Jin Tao; Zheng Hong; Tang Wei; Wu Chao; Jiao Jian Lin; Zhao Hong Bin

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Li Jin Tao , Zheng Hong , Tang Wei , Wu Chao , Jiao Jian Lin , Zhao Hong Bin . Effects of Different Feeding Space on Estradiol and Bone Metabolism Index in Tree Shrews with Osteoporosis[J]. Journal of Kunming Medical University, 2017, 38(09): 1-6.

Citation:

Li Jin Tao , Zheng Hong , Tang Wei , Wu Chao , Jiao Jian Lin , Zhao Hong Bin . Effects of Different Feeding Space on Estradiol and Bone Metabolism Index in Tree Shrews with Osteoporosis[J]. Journal of Kunming Medical University, 2017, 38(09): 1-6.

Citation:

Li Jin Tao , Zheng Hong , Tang Wei , Wu Chao , Jiao Jian Lin , Zhao Hong Bin . Effects of Different Feeding Space on Estradiol and Bone Metabolism Index in Tree Shrews with Osteoporosis[J]. Journal of Kunming Medical University, 2017, 38(09): 1-6.

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Effects of Different Feeding Space on Estradiol and Bone Metabolism Index in Tree Shrews with Osteoporosis

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基金：国家自然科学基金资助项目 (81460647); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2014FB033, 2012FB022) ;云南省科技厅-昆明医科大学应用基础研究联合专项基金青年博士项目[2017FE467 (-128) ];

Received Date: 2017-04-21

Abstract

Abstract

Objective To research the influence of different feeding space on spatial change index of estradiol and bone metabolism with in tree shrews osteoporosis after fracture.Methods Tree shrews with osteoporosis after fracture were randomly divided into fracture group (S1) , steamed dumplings without fracture group (S2) , a large cage fracture group (B1) , a large cage without fracture group (B2) four groups, in the space of different sizes in the cage for 90 days, the heart blood ELISA Kit the box according to the instructions to examine the content of serum E2, OC, PINP, CTX, TRACP-5 b, test data were statistically analyzed by SPSS 17 software.Results In the same feeding space, serum E2 (18.90±1.54, 38.25 ±3.33) of tree shrew in S1 group and B1 group were significantly lower than S2 group and B2 group (37.53±1.49, 60.40±2.42) (P<0.05) .The bone formation marker OC (3038.98±492.74, 2792.96±387.23) , PINP (27.39±3.04, 28.75±4.05) and bone absorption markers CTX (411.39±19.44, 324.67±41.32) , TRACP-5 b (2564.38±213.88, 2106.36±322.99) in S1 group and B1 groupwere significantly higher than that of S2 group and B2 group (OC 1835±247.47、1674.44±273.98, PINP 21.04 ±2.93、 19.65 ±2.29, CTX 211.95 ±19.44, 176.07 ±24.95, TRACP-5 b 1394.38 ±171.15、1404.10±210.25) (P<0.05) .Under different feeding space, Serum E2 (18.90±1.54) in S1 group was significantly lower than that of B1 group (38.25±3.33) and B2 group (60.40±2.42) (P<0.05) .CTX (411.39 ± 19.44) in S1 group was significantly higher than that of B1 group CTX (324.67±41.32) , B2 group (176.07±24.95) (P<0.05) , TRACP-5 b (2564.38±213.88) in S1 group was significantly higher than that of B1 group (2106.36±322.99) (P<0.05) .Conclusion Different feeding space size can cause the changes of estradiol and bone metabolism in tree shrews with osteoporosis after fracture.
- Feeding space,
- Osteoporosis,
- Tupaia belangeri chinensis,
- Estradiol,
- Bone metabolic index

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References(30)

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