Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation

Liu Hu Jun; Gao Li Ping

Volume 38 Issue 09

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Liu Hu Jun , Gao Li Ping . Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation[J]. Journal of Kunming Medical University, 2017, 38(09): 119-123.

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Liu Hu Jun , Gao Li Ping . Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation[J]. Journal of Kunming Medical University, 2017, 38(09): 119-123.

Citation:

Liu Hu Jun , Gao Li Ping . Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation[J]. Journal of Kunming Medical University, 2017, 38(09): 119-123.

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Influences of Different Doses of Ambroxol Hydrochloride Injection on Inflammatory Cytokines in Treatment of Elderly Patients with Chronic Obstructive Pulmonary Disease with Acute Exacerbation

Liu Hu Jun ,
Gao Li Ping

Funds:

基金：陕西省社会发展科技攻关项目 (2016SF-151);

Received Date: 2017-04-23

Abstract

Abstract

Objective To study the influences of different doses of Ambroxol Hydrochloride Injection on the inflammatory cotokines in the treatment of elderly patients with chronic obstructive pulmonary disease patients with acute exacerbation.Methods 62 cases of elderly patients with chronic obstructive pulmonary disease with acute exacerbation in our hospital from May 2015 to May 2016 were selected and randomly divided into Group A and B, 31 cases in each group.The Group A was given Ambroxol Hydrochloride Injection treatment, 330 mg per time, and Group B was given 90 mg Ambroxol Hydrochloride Injection treatment.The IL-6, IL-8, and TNF-α Index on the1 st day, 4 th day and 7 th day after the treatment in these two groups were compared.Results On the 1 st day, the sputum IL-6, IL-8 and TNF-αafter treatment had no statistically significant difference between two groups (P>0.05) .On the first 4 th day and 7 th day, the decrease of the indicators of patients in A group was significantly better than group B patients, and the difference was statistically significant (P<0.05) .There was no significant difference in the incidence of adverse reactions between the two groups (P > 0.05) .Conclusion The application of large doses of short Ambroxol Hydrochloride Injection can quickly improve the clinical symptoms in acute exacerbation of elderly patients with chronic obstructive pulmonary disease, and reduce the patient's sputum IL-6, IL-8 and TNF-α index, has better anti-inflammatory effect and deserves wide application.
- Ambroxol,
- Elderly patients with chronic obstructive pulmonary disease,
- Inflammatory cytokines

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