Mutiple Myeloma with Double Clones of IgD-λ+λ:Two Cases Report

Wang Xue Jiao; Zhang Zhe; Yu Jing Xing; Li Yuan Yuan; Zhao Mei Shu; Yin Lie Fen

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Wang Xue Jiao , Zhang Zhe , Yu Jing Xing , Li Yuan Yuan , Zhao Mei Shu , Yin Lie Fen . Mutiple Myeloma with Double Clones of IgD-λ+λ:Two Cases Report[J]. Journal of Kunming Medical University, 2017, 38(09): 124-128.

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Wang Xue Jiao , Zhang Zhe , Yu Jing Xing , Li Yuan Yuan , Zhao Mei Shu , Yin Lie Fen . Mutiple Myeloma with Double Clones of IgD-λ+λ:Two Cases Report[J]. Journal of Kunming Medical University, 2017, 38(09): 124-128.

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Mutiple Myeloma with Double Clones of IgD-λ+λ:Two Cases Report

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基金：云南省科技计划基金资助项目 (2011FBl98); 云南省科技厅应用基础研究联合专项基金资助项目 (2013FB151);

Received Date: 2017-04-12

Abstract

Abstract

Objective To improve the recognition level, diagnostic therapeutic level of IgD-λ+λ type mutiple myeloma, and also reduce the rate of missed diagnosis and misdiagnosis.Methods We retrospectively reported and analyzed two cases double clones of IgD-λ+λ type multiple myelomadiagnosed in our hospital from January to November in 2014.Results There were 79 cases of multiple myeloma patients during observing time.Two patients in this study, male one was 45 years old while the female one 51 years old when they first came to be diagnosed.Both of them were diagnosed of double clones of IgD-λ+λ stage Ⅲ B group.Clinical manifestation included anemia, ostealgia, renal failure, thin and weak.Serum calcium and LDH levels were increased in different degree.The levels of immune globulin IgG, IgA, IgM were decreased and immunofixation electrophresis showed two monoclonal zone.Then they were both diagnosed IgD-λ+λ type mutiple myelom.One patient reached PR after four courses VADT chemotherapy and now is still alive.Another one didn't accept any treatment because of poverty.Conclusions The double clones IgD-λ+λ type multiple myelomais is a kind of rare plasma cell disorder, sicientists now haven't reached a profond understanding about its clinical features, laboratory features diagnositic criteria and therapeutic prognosis.More clinical cases are needed to summarize and analyze in the future study.
- Double clones,
- Multiple myeloma,
- IgD-λ+λ,
- Immunofixation

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References(21)

References

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