The Expression and Clinical Significance in of Protein Markers Pulmonary Large cell Carcinoma

Ma Yuan; Zhan Zhong Li; Sun Bao Cun; Zhao Yong He; Hu Zao Xiu

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Ma Yuan , Zhan Zhong Li , Sun Bao Cun , Zhao Yong He , Hu Zao Xiu . The Expression and Clinical Significance in of Protein Markers Pulmonary Large cell Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(09): 30-34.

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Ma Yuan , Zhan Zhong Li , Sun Bao Cun , Zhao Yong He , Hu Zao Xiu . The Expression and Clinical Significance in of Protein Markers Pulmonary Large cell Carcinoma[J]. Journal of Kunming Medical University, 2017, 38(09): 30-34.

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The Expression and Clinical Significance in of Protein Markers Pulmonary Large cell Carcinoma

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基金：云南省应用基础研究计划基金资助项目 (2013FZ072); 云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (2013FB117);

Received Date: 2017-05-10

Abstract

Abstract

Objective To investigate the expression and clinical significance in of protein markers pulmonary large cell carcinoma (PLCC) .Methods We detected the expression of protein markers of PLCC, and classified the PLCC.We also evaluated the sensibility and specificity of the protein markser.Results The PLCC expressed different protein markers:CK7, TTF1, Napsin A, CK5/6, p63, SOX2, p40, CgA and Syn.The sensibility and specificity of CK7, TTF1, Napsin A was 100%, 63.33%, 76.67% and 62.5%, 100%, 100%.The sensibility and specificity of CK5/6, p63, SOX2, p40 was 100%, 87.5%, 87.5%, 87.5% and 73.33%, 83.33%, 96.67%, 96.67%.The difference of lymph node metastasis rate of every type of pulmonary large cell carcinoma had no statistical significance (P>0.05) , the difference of mutation rate of EGFR of every type of pulmonary large cell carcinoma was statistically significant ( P <0.05) , stem carcinoma>adenocarcinoma>squamous carcinoma.Conclusion It is necessary to detect protein markers of pulmonary large cell carcinoma and their classification.It is helpful to clinical prognosis and to establish reasonable and effective individualized treatment.The sequence number of the sensibility and specificity to adenocarcinoma is Napsin A>TTF1>CK7, to squamous carcinoma is SOX2=p40>p63>CK5/6.
- Large cell carcinoma,
- Protein marker,
- Classification,
- Sensibility,
- Specificity,
- Individualized treatment

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References(8)

References

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