Relationship between Single Nucleotide Polymorphisms of ERCC Gene and Survival of Osteosarcoma

Zhang Jin Yu; Peng Zhuo Hui

Volume 38 Issue 09

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Zhang Jin Yu , Peng Zhuo Hui . Relationship between Single Nucleotide Polymorphisms of ERCC Gene and Survival of Osteosarcoma[J]. Journal of Kunming Medical University, 2017, 38(09): 59-65.

Citation:

Zhang Jin Yu , Peng Zhuo Hui . Relationship between Single Nucleotide Polymorphisms of ERCC Gene and Survival of Osteosarcoma[J]. Journal of Kunming Medical University, 2017, 38(09): 59-65.

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Relationship between Single Nucleotide Polymorphisms of ERCC Gene and Survival of Osteosarcoma

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目 (20147FZ038);

Received Date: 2017-04-21

Abstract

Abstract

Objective To study the relationship between single nucleotide polymorphisms (SNPs) of ERCC1 Asn118 Asn (rs11615) , ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn (rs1799793) and ERCC2 Lys751 Gln (rs13181) and osteosarcoma survival with the osteosarcoma patients.Methods 161 patients with osteosarcoma in our hospital from January 2010 to Decemher 2015 and 163 heahhy adults were enrolled in this study.2 m L peripheral blood samples were taken from each person.The RT-q PCR method was used to detect the genotype and allele frequency distribution of ERCC1 Asn118 Asn (rs11615) , ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn (rs1799793) and ERCC2 Lys751 Gln (rs13181) in osteosarcoma patients and normal population.Osteosarcoma patients were divided into several groups according to the clinical parameters such as age, gender, histology, tumor location, Enneking classification, tumormetastasis and therapy, and analyzed the relations between the genetic polymorphism and clinical parameters.Results For ERCC1 Asn118 Asn, thevariant genotype T/T was strongly significantly associated with a higher disease-free survival when compared with the wild-type C/C, with an adjusted OR (95% CI) of 0.37 (0.15-0.85) .ERCC2 751 A/A genotype showed increased disease-free survival of osteosarcoma (HR=0.45; 95% CI=0.11-0.88) .However, we did not find significant association of ERCC1 Gln504 Lys and ERCC2 Asp312 Asn polymorphisms with prognosis of osteosarcoma.Conclusions The genetic polymorphism of ERCC gene at ERCC1 Asn118 Asn T/T, ERCC2 Lys751 Gln A/A is associated with osteosarcoma disease-free survival (SFS) , can be used as clinical prognostic markers for osteosarcoma patients with cisplatin treatment.But ERCC1 Gln504 Lys (rs3212986) , ERCC2 Asp312 Asn have no correlation with osteosarcoma disease-free survival (SFS) .
- Osteosarcoma,
- ERCC1,
- ERCC2,
- Polymorphism,
- Survival,
- Cisplain treatment

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