In Vitro Anticancer Effects of Lichen Bioactive Compound C11H12O5

Jiang Zhong Yang; He Xiao Qiong; Yao Qian; Shui Jing Lin

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Jiang Zhong Yang , He Xiao Qiong , Yao Qian , Shui Jing Lin . In Vitro Anticancer Effects of Lichen Bioactive Compound C11H12O5[J]. Journal of Kunming Medical University, 2017, 38(09): 7-10.

Citation:

Jiang Zhong Yang , He Xiao Qiong , Yao Qian , Shui Jing Lin . In Vitro Anticancer Effects of Lichen Bioactive Compound C11H12O5[J]. Journal of Kunming Medical University, 2017, 38(09): 7-10.

Jiang Zhong Yang , He Xiao Qiong , Yao Qian , Shui Jing Lin . In Vitro Anticancer Effects of Lichen Bioactive Compound C11H12O5[J]. Journal of Kunming Medical University, 2017, 38(09): 7-10.

Citation:

Jiang Zhong Yang , He Xiao Qiong , Yao Qian , Shui Jing Lin . In Vitro Anticancer Effects of Lichen Bioactive Compound C11H12O5[J]. Journal of Kunming Medical University, 2017, 38(09): 7-10.

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In Vitro Anticancer Effects of Lichen Bioactive Compound C11H12O5

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基金：云南省科技厅-昆明医科大学应用基础研究联合专项基金重点资助项目 (2012FB001); 昆明医科大学重大科技成果培育基金资助项目 (CGPY201603);

Received Date: 2017-03-19

Abstract

Abstract

Objectives To investigate the in vitro anticancer effects of lichen bioactive compound C11H12O5 on human breast cancer cell line MCF-7, human hepatoma cell line HepG2, human lung adenocarcinoma cell line A-549, and observe the dose-effect and time-effect.Methods MTT assay was used in the in vitro anticancer study.The OD values at 24 h, 48 h, 72 h were examined and the inhibitory ratios were calculated.Results The inhibitory ratios were 14.19%, 13.84%, 28.90%, 59.50%, 80.29% in MCF-7;3.89%, 11.09%, 21.66%, 46.27% and 66.69% in HepG2 and 14.13%, 11.09%, 45.98%, 86.19%, 99.02% in A-549 at 2, 4, 8, 16, 32 μg/m L of compound C11H12O5.The IC50 were 12.43 μg/m L, 18.88 μg/m L and 6.21 μg/m L in MCF-7, HepG2 and A-549 respectively.Conclusions Compound C11H12O5 has significant in vitro anticancer effects on MCF-7, HepG2, A-549.The anticancer effects is dose dependent.A-549 is the most sensitive cell line.The timeeffect of the in vitro anticancer effect in A-549 is not evident.
- Lichen,
- In vitro anticancer effect,
- MTT assay,
- MCF-7,
- HepG2,
- A-549

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References(20)

References

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